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000165175 1001_ $$aLeblanc, Pascal$$b0
000165175 245__ $$aViruses in neurodegenerative diseases: More than just suspects in crimes.
000165175 260__ $$aLawrence, Kan.$$bPLoS$$c2022
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000165175 520__ $$aNeurodegenerative diseases (NDs) such as Alzheimer's and Parkinson's disease are fatal neurological diseases that can be of idiopathic, genetic, or even infectious origin, as in the case of transmissible spongiform encephalopathies. The etiological factors that lead to neurodegeneration remain unknown but likely involve a combination of aging, genetic risk factors, and environmental stressors. Accumulating evidence hints at an association of viruses with neurodegenerative disorders and suggests that virus-induced neuroinflammation and perturbation of neuronal protein quality control can be involved in the early steps of disease development. In this review, we focus on emerging evidence for a correlation between NDs and viral infection and discuss how viral manipulations of cellular processes can affect the formation and dissemination of disease-associated protein aggregates.
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000165175 650_2 $$2MeSH$$aAging
000165175 650_2 $$2MeSH$$aCrime
000165175 650_2 $$2MeSH$$aHumans
000165175 650_2 $$2MeSH$$aNeurodegenerative Diseases
000165175 650_2 $$2MeSH$$aPrion Diseases
000165175 650_2 $$2MeSH$$aViruses
000165175 7001_ $$0P:(DE-2719)2481765$$aVorberg, Ina$$b1$$eLast author$$udzne
000165175 773__ $$0PERI:(DE-600)2205412-1$$a10.1371/journal.ppat.1010670$$gVol. 18, no. 8, p. e1010670 -$$n8$$pe1010670$$tPLoS pathogens$$v18$$x1553-7366$$y2022
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