Journal Article (Review Article)

DZNE-2022-01477

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Viruses in neurodegenerative diseases: More than just suspects in crimes.

Leblanc, P. ; Vorberg, I. (Last author)DZNE*

2022
PLoS Lawrence, Kan.

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Please use a persistent id in citations: doi:10.1371/journal.ppat.1010670

Abstract: Neurodegenerative diseases (NDs) such as Alzheimer's and Parkinson's disease are fatal neurological diseases that can be of idiopathic, genetic, or even infectious origin, as in the case of transmissible spongiform encephalopathies. The etiological factors that lead to neurodegeneration remain unknown but likely involve a combination of aging, genetic risk factors, and environmental stressors. Accumulating evidence hints at an association of viruses with neurodegenerative disorders and suggests that virus-induced neuroinflammation and perturbation of neuronal protein quality control can be involved in the early steps of disease development. In this review, we focus on emerging evidence for a correlation between NDs and viral infection and discuss how viral manipulations of cellular processes can affect the formation and dissemination of disease-associated protein aggregates.

Keyword(s): Aging (MeSH) ; Crime (MeSH) ; Humans (MeSH) ; Neurodegenerative Diseases (MeSH) ; Prion Diseases (MeSH) ; Viruses (MeSH)

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Contributing Institute(s):

1. Prion Cell Biology (AG Vorberg)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2022

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