TY  - JOUR
AU  - Leblanc, Pascal
AU  - Vorberg, Ina
TI  - Viruses in neurodegenerative diseases: More than just suspects in crimes.
JO  - PLoS pathogens
VL  - 18
IS  - 8
SN  - 1553-7366
CY  - Lawrence, Kan.
PB  - PLoS
M1  - DZNE-2022-01477
SP  - e1010670
PY  - 2022
AB  - Neurodegenerative diseases (NDs) such as Alzheimer's and Parkinson's disease are fatal neurological diseases that can be of idiopathic, genetic, or even infectious origin, as in the case of transmissible spongiform encephalopathies. The etiological factors that lead to neurodegeneration remain unknown but likely involve a combination of aging, genetic risk factors, and environmental stressors. Accumulating evidence hints at an association of viruses with neurodegenerative disorders and suggests that virus-induced neuroinflammation and perturbation of neuronal protein quality control can be involved in the early steps of disease development. In this review, we focus on emerging evidence for a correlation between NDs and viral infection and discuss how viral manipulations of cellular processes can affect the formation and dissemination of disease-associated protein aggregates.
KW  - Aging
KW  - Crime
KW  - Humans
KW  - Neurodegenerative Diseases
KW  - Prion Diseases
KW  - Viruses
LB  - PUB:(DE-HGF)16
C6  - pmid:35925897
C2  - pmc:PMC9352104
DO  - DOI:10.1371/journal.ppat.1010670
UR  - https://pub.dzne.de/record/165175
ER  -