Journal Article

DZNE-2022-01746

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dentate gyrus astrocytes exhibit layer-specific molecular, morphological and physiological features.

Karpf, J. ; Unichenko, P. ; Chalmers, N. ; Beyer, F. ; Wittmann, M.-T. ; Schneider, J. ; Fidan, E. ; Reis, A. ; Beckervordersandforth, J. ; Brandner, S. ; Liebner, S. ; Falk, S. ; Sagner, A. ; Henneberger, C.DZNE* ; Beckervordersandforth, R.

2022
Nature America New York, NY

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Please use a persistent id in citations: doi:10.1038/s41593-022-01192-5

Abstract: Neuronal heterogeneity has been established as a pillar of higher central nervous system function, but glial heterogeneity and its implications for neural circuit function are poorly understood. Here we show that the adult mouse dentate gyrus (DG) of the hippocampus is populated by molecularly distinct astrocyte subtypes that are associated with distinct DG layers. Astrocytes localized to different DG compartments also exhibit subtype-specific morphologies. Physiologically, astrocytes in upper DG layers form large syncytia, while those in lower DG compartments form smaller networks. Astrocyte subtypes differentially express glutamate transporters, which is associated with different amplitudes of glutamate transporter-mediated currents. Key molecular and morphological features of astrocyte diversity in the mice DG are conserved in humans. This adds another layer of complexity to our understanding of brain network composition and function, which will be crucial for further studies on astrocytes in health and disease.

Keyword(s): Adult (MeSH) ; Humans (MeSH) ; Animals (MeSH) ; Mice (MeSH) ; Astrocytes (MeSH) ; Neuroglia (MeSH) ; Hippocampus (MeSH) ; Brain (MeSH) ; Dentate Gyrus (MeSH)

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Contributing Institute(s):

1. Synaptic and Glial Plasticity (AG Henneberger)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)

Appears in the scientific report 2022

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 25 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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