%0 Chart or Table
%A Teipel, Stefan
%A Fritz, Hans-Christian
%A Grothe, Michel
%T Dataset: Neuropathological features associated with basal forebrain atrophy in Alzheimer’s disease
%I Dryad
%M DZNE-2022-01785
%D 2020
%X Objective: To study the neuropathological correlates of cholinergic basal forebrain atrophy as determined using ante-mortem MRI in the Alzheimer’s disease (AD) spectrum. Methods: We determined associations between basal forebrain (BF) volume from antemortem MRI brain scans and post-mortem assessment of neuropathological features, including neuritic plaques, neurofibrillary tangles (NFT), Lewy body (LB) pathology, and TDP-43, in 64 cases of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort. For comparison, we assessed neuropathological features associated with hippocampal and parahippocampal gyrus atrophy. In addition to region of interest-based analysis, we determined the association of neuropathological features with whole brain grey matter volume using regionally unbiased voxel-based volumetry. Results: BF atrophy was associated with Thal amyloid phases (95
%K amyloid (Other)
%K Neuropathology (Other)
%K Alzheimer's disease (Other)
%K MRI (Other)
%K memory (Other)
%F PUB:(DE-HGF)32
%9 Dataset
%R 10.5061/dryad.dfn2z34x6
%U https://pub.dzne.de/record/169078