Dataset

DZNE-2022-01785

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dataset: Neuropathological features associated with basal forebrain atrophy in Alzheimer’s disease

Teipel, S. (First author)DZNE* ; Fritz, H.-C.Extern* ; Grothe, M. (Last author)DZNE*

2020
Dryad

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Please use a persistent id in citations: doi:10.5061/DRYAD.DFN2Z34X6  doi:10.5061/dryad.dfn2z34x6

Abstract: Objective: To study the neuropathological correlates of cholinergic basal forebrain atrophy as determined using ante-mortem MRI in the Alzheimer’s disease (AD) spectrum. Methods: We determined associations between basal forebrain (BF) volume from antemortem MRI brain scans and post-mortem assessment of neuropathological features, including neuritic plaques, neurofibrillary tangles (NFT), Lewy body (LB) pathology, and TDP-43, in 64 cases of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort. For comparison, we assessed neuropathological features associated with hippocampal and parahippocampal gyrus atrophy. In addition to region of interest-based analysis, we determined the association of neuropathological features with whole brain grey matter volume using regionally unbiased voxel-based volumetry. Results: BF atrophy was associated with Thal amyloid phases (95% confidence interval -0.49 - -0.01, p=0.049) and presence of LB pathology (95% CI -0.54 - -0.06, p=0.015), as well as with the degree of LB pathology within the Nucleus basalis Meynert (NbM) (95% CI -0.54 - -0.07, p=0.025). These effects were no more significant after false discovery rate (FDR) correction. Hippocampal atrophy was significantly associated with the presence of TDP-43 pathology (95% CI 0.61 - -0.17, p=0.003; surviving FDR correction), in addition to dentate gyrus NFT load (95% CI -0.49 - 0.01, p = 0.044; uncorrected). Voxel-based analysis confirmed spatially restricted effects of Thal phases and presence of LB pathology on BF volume. Conclusions: These findings indicate that neuropathological correlates of regional atrophy differ substantially between different brain regions that are typically involved in AD-related neurodegeneration, including different susceptibilities to common co-morbid pathologies.

Keyword(s): amyloid ; Neuropathology ; Alzheimer's disease ; MRI ; memory

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Contributing Institute(s):

1. Clinical Dementia Research (Rostock /Greifswald) (AG Teipel)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2020

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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article Teipel, S. J. (First author)DZNE* ; Fritz, H.-C.DZNE* ; Grothe, M. (Last author)DZNE* ; et al
Neuropathologic features associated with basal forebrain atrophy in Alzheimer disease.
Neurology 95(10), e1301 - e1311 (2020) [10.1212/WNL.0000000000010192]2020   Fulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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