000169078 001__ 169078
000169078 005__ 20230906150601.0
000169078 0247_ $$2doi$$a10.5061/DRYAD.DFN2Z34X6
000169078 0247_ $$2doi$$a10.5061/dryad.dfn2z34x6
000169078 037__ $$aDZNE-2022-01785
000169078 041__ $$aEnglish
000169078 1001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan$$b0$$eFirst author$$udzne
000169078 245__ $$aDataset: Neuropathological features associated with basal forebrain atrophy in Alzheimer’s disease
000169078 260__ $$bDryad$$c2020
000169078 3367_ $$2BibTeX$$aMISC
000169078 3367_ $$0PUB:(DE-HGF)32$$2PUB:(DE-HGF)$$aDataset$$bdataset$$mdataset$$s1694005549_1589
000169078 3367_ $$026$$2EndNote$$aChart or Table
000169078 3367_ $$2DataCite$$aDataset
000169078 3367_ $$2ORCID$$aDATA_SET
000169078 3367_ $$2DINI$$aResearchData
000169078 520__ $$aObjective: To study the neuropathological correlates of cholinergic basal forebrain atrophy as determined using ante-mortem MRI in the Alzheimer’s disease (AD) spectrum. Methods: We determined associations between basal forebrain (BF) volume from antemortem MRI brain scans and post-mortem assessment of neuropathological features, including neuritic plaques, neurofibrillary tangles (NFT), Lewy body (LB) pathology, and TDP-43, in 64 cases of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort. For comparison, we assessed neuropathological features associated with hippocampal and parahippocampal gyrus atrophy. In addition to region of interest-based analysis, we determined the association of neuropathological features with whole brain grey matter volume using regionally unbiased voxel-based volumetry. Results: BF atrophy was associated with Thal amyloid phases (95% confidence interval -0.49 - -0.01, p=0.049) and presence of LB pathology (95% CI -0.54 - -0.06, p=0.015), as well as with the degree of LB pathology within the Nucleus basalis Meynert (NbM) (95% CI -0.54 - -0.07, p=0.025). These effects were no more significant after false discovery rate (FDR) correction. Hippocampal atrophy was significantly associated with the presence of TDP-43 pathology (95% CI 0.61 - -0.17, p=0.003; surviving FDR correction), in addition to dentate gyrus NFT load (95% CI -0.49 - 0.01, p = 0.044; uncorrected). Voxel-based analysis confirmed spatially restricted effects of Thal phases and presence of LB pathology on BF volume. Conclusions: These findings indicate that neuropathological correlates of regional atrophy differ substantially between different brain regions that are typically involved in AD-related neurodegeneration, including different susceptibilities to common co-morbid pathologies.
000169078 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0
000169078 588__ $$aDataset connected to DataCite
000169078 650_7 $$2Other$$aamyloid
000169078 650_7 $$2Other$$aNeuropathology
000169078 650_7 $$2Other$$aAlzheimer's disease
000169078 650_7 $$2Other$$aMRI
000169078 650_7 $$2Other$$amemory
000169078 7001_ $$0P:(DE-2719)2811931$$aFritz, Hans-Christian$$b1$$udzne
000169078 7001_ $$0P:(DE-2719)2810708$$aGrothe, Michel$$b2$$eLast author$$udzne
000169078 773__ $$a10.5061/dryad.dfn2z34x6
000169078 909CO $$ooai:pub.dzne.de:169078$$pVDB
000169078 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000026$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000169078 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2811931$$aExternal Institute$$b1$$kExtern
000169078 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810708$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000169078 9131_ $$0G:(DE-HGF)POF4-353$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vClinical and Health Care Research$$x0
000169078 9141_ $$y2020
000169078 9201_ $$0I:(DE-2719)1510100$$kAG Teipel$$lClinical Dementia Research (Rostock /Greifswald)$$x0
000169078 980__ $$adataset
000169078 980__ $$aVDB
000169078 980__ $$aI:(DE-2719)1510100
000169078 980__ $$aUNRESTRICTED