TY  - CHART
AU  - Teipel, Stefan
AU  - Fritz, Hans-Christian
AU  - Grothe, Michel
TI  - Dataset: Neuropathological features associated with basal forebrain atrophy in Alzheimer’s disease
PB  - Dryad
M1  - DZNE-2022-01785
PY  - 2020
AB  - Objective: To study the neuropathological correlates of cholinergic basal forebrain atrophy as determined using ante-mortem MRI in the Alzheimer’s disease (AD) spectrum. Methods: We determined associations between basal forebrain (BF) volume from antemortem MRI brain scans and post-mortem assessment of neuropathological features, including neuritic plaques, neurofibrillary tangles (NFT), Lewy body (LB) pathology, and TDP-43, in 64 cases of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort. For comparison, we assessed neuropathological features associated with hippocampal and parahippocampal gyrus atrophy. In addition to region of interest-based analysis, we determined the association of neuropathological features with whole brain grey matter volume using regionally unbiased voxel-based volumetry. Results: BF atrophy was associated with Thal amyloid phases (95
KW  - amyloid (Other)
KW  - Neuropathology (Other)
KW  - Alzheimer's disease (Other)
KW  - MRI (Other)
KW  - memory (Other)
LB  - PUB:(DE-HGF)32
DO  - DOI:10.5061/dryad.dfn2z34x6
UR  - https://pub.dzne.de/record/169078
ER  -