% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@MISC{Teipel:169078,
      author       = {Teipel, Stefan and Fritz, Hans-Christian and Grothe,
                      Michel},
      title        = {{D}ataset: {N}europathological features associated with
                      basal forebrain atrophy in {A}lzheimer’s disease},
      publisher    = {Dryad},
      reportid     = {DZNE-2022-01785},
      year         = {2020},
      abstract     = {Objective: To study the neuropathological correlates of
                      cholinergic basal forebrain atrophy as determined using
                      ante-mortem MRI in the Alzheimer’s disease (AD) spectrum.
                      Methods: We determined associations between basal forebrain
                      (BF) volume from antemortem MRI brain scans and post-mortem
                      assessment of neuropathological features, including neuritic
                      plaques, neurofibrillary tangles (NFT), Lewy body (LB)
                      pathology, and TDP-43, in 64 cases of the Alzheimer’s
                      Disease Neuroimaging Initiative (ADNI) cohort. For
                      comparison, we assessed neuropathological features
                      associated with hippocampal and parahippocampal gyrus
                      atrophy. In addition to region of interest-based analysis,
                      we determined the association of neuropathological features
                      with whole brain grey matter volume using regionally
                      unbiased voxel-based volumetry. Results: BF atrophy was
                      associated with Thal amyloid phases $(95\%$ confidence
                      interval -0.49 - -0.01, p=0.049) and presence of LB
                      pathology $(95\%$ CI -0.54 - -0.06, p=0.015), as well as
                      with the degree of LB pathology within the Nucleus basalis
                      Meynert (NbM) $(95\%$ CI -0.54 - -0.07, p=0.025). These
                      effects were no more significant after false discovery rate
                      (FDR) correction. Hippocampal atrophy was significantly
                      associated with the presence of TDP-43 pathology $(95\%$ CI
                      0.61 - -0.17, p=0.003; surviving FDR correction), in
                      addition to dentate gyrus NFT load $(95\%$ CI -0.49 - 0.01,
                      p = 0.044; uncorrected). Voxel-based analysis confirmed
                      spatially restricted effects of Thal phases and presence of
                      LB pathology on BF volume. Conclusions: These findings
                      indicate that neuropathological correlates of regional
                      atrophy differ substantially between different brain regions
                      that are typically involved in AD-related neurodegeneration,
                      including different susceptibilities to common co-morbid
                      pathologies.},
      keywords     = {amyloid (Other) / Neuropathology (Other) / Alzheimer's
                      disease (Other) / MRI (Other) / memory (Other)},
      cin          = {AG Teipel},
      cid          = {I:(DE-2719)1510100},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)32},
      doi          = {10.5061/dryad.dfn2z34x6},
      url          = {https://pub.dzne.de/record/169078},
}