Home > Publications Database > Dataset: Neuropathological features associated with basal forebrain atrophy in Alzheimer’s disease > print

001     169078
005     20230906150601.0
024 7 _ |a 10.5061/DRYAD.DFN2Z34X6
|2 doi
024 7 _ |a 10.5061/dryad.dfn2z34x6
|2 doi
037 _ _ |a DZNE-2022-01785
041 _ _ |a English
100 1 _ |a Teipel, Stefan
|0 P:(DE-2719)2000026
|b 0
|e First author
|u dzne
245 _ _ |a Dataset: Neuropathological features associated with basal forebrain atrophy in Alzheimer’s disease
260 _ _ |c 2020
|b Dryad
336 7 _ |a MISC
|2 BibTeX
336 7 _ |a Dataset
|b dataset
|m dataset
|0 PUB:(DE-HGF)32
|s 1694005549_1589
|2 PUB:(DE-HGF)
336 7 _ |a Chart or Table
|0 26
|2 EndNote
336 7 _ |a Dataset
|2 DataCite
336 7 _ |a DATA_SET
|2 ORCID
336 7 _ |a ResearchData
|2 DINI
520 _ _ |a Objective: To study the neuropathological correlates of cholinergic basal forebrain atrophy as determined using ante-mortem MRI in the Alzheimer’s disease (AD) spectrum. Methods: We determined associations between basal forebrain (BF) volume from antemortem MRI brain scans and post-mortem assessment of neuropathological features, including neuritic plaques, neurofibrillary tangles (NFT), Lewy body (LB) pathology, and TDP-43, in 64 cases of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort. For comparison, we assessed neuropathological features associated with hippocampal and parahippocampal gyrus atrophy. In addition to region of interest-based analysis, we determined the association of neuropathological features with whole brain grey matter volume using regionally unbiased voxel-based volumetry. Results: BF atrophy was associated with Thal amyloid phases (95% confidence interval -0.49 - -0.01, p=0.049) and presence of LB pathology (95% CI -0.54 - -0.06, p=0.015), as well as with the degree of LB pathology within the Nucleus basalis Meynert (NbM) (95% CI -0.54 - -0.07, p=0.025). These effects were no more significant after false discovery rate (FDR) correction. Hippocampal atrophy was significantly associated with the presence of TDP-43 pathology (95% CI 0.61 - -0.17, p=0.003; surviving FDR correction), in addition to dentate gyrus NFT load (95% CI -0.49 - 0.01, p = 0.044; uncorrected). Voxel-based analysis confirmed spatially restricted effects of Thal phases and presence of LB pathology on BF volume. Conclusions: These findings indicate that neuropathological correlates of regional atrophy differ substantially between different brain regions that are typically involved in AD-related neurodegeneration, including different susceptibilities to common co-morbid pathologies.
536 _ _ |a 353 - Clinical and Health Care Research (POF4-353)
|0 G:(DE-HGF)POF4-353
|c POF4-353
|f POF IV
|x 0
588 _ _ |a Dataset connected to DataCite
650 _ 7 |a amyloid
|2 Other
650 _ 7 |a Neuropathology
|2 Other
650 _ 7 |a Alzheimer's disease
|2 Other
650 _ 7 |a MRI
|2 Other
650 _ 7 |a memory
|2 Other
700 1 _ |a Fritz, Hans-Christian
|0 P:(DE-2719)2811931
|b 1
|u dzne
700 1 _ |a Grothe, Michel
|0 P:(DE-2719)2810708
|b 2
|e Last author
|u dzne
773 _ _ |a 10.5061/dryad.dfn2z34x6
909 C O |p VDB
|o oai:pub.dzne.de:169078
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 0
|6 P:(DE-2719)2000026
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 1
|6 P:(DE-2719)2811931
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 2
|6 P:(DE-2719)2810708
913 1 _ |a DE-HGF
|b Gesundheit
|l Neurodegenerative Diseases
|1 G:(DE-HGF)POF4-350
|0 G:(DE-HGF)POF4-353
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-300
|4 G:(DE-HGF)POF
|v Clinical and Health Care Research
|x 0
914 1 _ |y 2020
920 1 _ |0 I:(DE-2719)1510100
|k AG Teipel
|l Clinical Dementia Research (Rostock /Greifswald)
|x 0
980 _ _ |a dataset
980 _ _ |a VDB
980 _ _ |a I:(DE-2719)1510100
980 _ _ |a UNRESTRICTED

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