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@ARTICLE{Pantazis:169132,
      author       = {Pantazis, Caroline B and Yang, Andrian and Lara, Erika and
                      McDonough, Justin A and Blauwendraat, Cornelis and Peng,
                      Lirong and Oguro, Hideyuki and Kanaujiya, Jitendra and Zou,
                      Jizhong and Sebesta, David and Pratt, Gretchen and Cross,
                      Erin and Blockwick, Jeffrey and Buxton, Philip and
                      Kinner-Bibeau, Lauren and Medura, Constance and Tompkins,
                      Christopher and Hughes, Stephen and Santiana, Marianita and
                      Faghri, Faraz and Nalls, Mike A and Vitale, Daniel and
                      Ballard, Shannon and Qi, Yue A and Ramos, Daniel M and
                      Anderson, Kailyn M and Stadler, Julia and Narayan, Priyanka
                      and Papademetriou, Jason and Reilly, Luke and Nelson,
                      Matthew P and Aggarwal, Sanya and Rosen, Leah U and Kirwan,
                      Peter and Pisupati, Venkat and Coon, Steven L and Scholz,
                      Sonja W and Priebe, Theresa and Öttl, Miriam and Dong, Jian
                      and Meijer, Marieke and Janssen, Lara J M and Lourenco,
                      Vanessa S and van der Kant, Rik and Crusius, Dennis and
                      Paquet, Dominik and Raulin, Ana-Caroline and Bu, Guojun and
                      Held, Aaron and Wainger, Brian J and Gabriele, Rebecca M C
                      and Casey, Jackie M and Wray, Selina and Abu-Bonsrah, Dad
                      and Parish, Clare L and Beccari, Melinda S and Cleveland,
                      Don W and Li, Emmy and Rose, Indigo V L and Kampmann, Martin
                      and Calatayud Aristoy, Carles and Verstreken, Patrik and
                      Heinrich, Laurin and Chen, Max Y and Schüle, Birgitt and
                      Dou, Dan and Holzbaur, Erika L F and Zanellati, Maria Clara
                      and Basundra, Richa and Deshmukh, Mohanish and Cohen, Sarah
                      and Khanna, Richa and Raman, Malavika and Nevin, Zachary S
                      and Matia, Madeline and Van Lent, Jonas and Timmerman,
                      Vincent and Conklin, Bruce R and Johnson Chase, Katherine
                      and Zhang, Ke and Funes, Salome and Bosco, Daryl A and
                      Erlebach, Lena and Welzer, Marc and Kronenberg-Versteeg,
                      Deborah and Lyu, Guochang and Arenas, Ernest and Coccia,
                      Elena and Sarrafha, Lily and Ahfeldt, Tim and Marioni, John
                      C and Skarnes, William C and Cookson, Mark R and Ward,
                      Michael E and Merkle, Florian T},
      title        = {{A} reference human induced pluripotent stem cell line for
                      large-scale collaborative studies.},
      journal      = {Cell stem cell},
      volume       = {29},
      number       = {12},
      issn         = {1934-5909},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2023-00011},
      pages        = {1685 - 1702.e22},
      year         = {2022},
      abstract     = {Human induced pluripotent stem cell (iPSC) lines are a
                      powerful tool for studying development and disease, but the
                      considerable phenotypic variation between lines makes it
                      challenging to replicate key findings and integrate data
                      across research groups. To address this issue, we sub-cloned
                      candidate human iPSC lines and deeply characterized their
                      genetic properties using whole genome sequencing, their
                      genomic stability upon CRISPR-Cas9-based gene editing, and
                      their phenotypic properties including differentiation to
                      commonly used cell types. These studies identified KOLF2.1J
                      as an all-around well-performing iPSC line. We then shared
                      KOLF2.1J with groups around the world who tested its
                      performance in head-to-head comparisons with their own
                      preferred iPSC lines across a diverse range of
                      differentiation protocols and functional assays. On the
                      strength of these findings, we have made KOLF2.1J and its
                      gene-edited derivative clones readily accessible to promote
                      the standardization required for large-scale collaborative
                      science in the stem cell field.},
      keywords     = {Humans / Induced Pluripotent Stem Cells / Cell
                      Differentiation / Gene Editing / Biological Assay / CRISPR
                      (Other) / differentiation (Other) / iPSC (Other) / karyotype
                      (Other) / p53 (Other) / pluripotent (Other) / reference
                      (Other) / single-cell (Other) / stem cell (Other) /
                      whole-genome (Other)},
      cin          = {AG Jucker / AG Rizzu},
      ddc          = {570},
      cid          = {I:(DE-2719)1210001 / I:(DE-2719)1210009},
      pnm          = {352 - Disease Mechanisms (POF4-352) / 354 - Disease
                      Prevention and Healthy Aging (POF4-354)},
      pid          = {G:(DE-HGF)POF4-352 / G:(DE-HGF)POF4-354},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36459969},
      pmc          = {pmc:PMC9782786},
      doi          = {10.1016/j.stem.2022.11.004},
      url          = {https://pub.dzne.de/record/169132},
}