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@MISC{Mller:248112,
      author       = {Müller, Stephan A and Lichtenthaler, Stefan},
      title        = {{D}ataset: {T}etraspanin {T}span15 is an essential subunit
                      of an {ADAM}10 scissor complex},
      publisher    = {PRoteomics IDEntifications Database},
      reportid     = {DZNE-2023-00216},
      year         = {2021},
      abstract     = {A disintegrin and metalloprotease 10 (ADAM10) is essential
                      for embryonic development and impacts on diseases such as
                      cancer, Alzheimer’s and inflammatory diseases. ADAM10 is a
                      ‘molecular scissor’ that proteolytically cleaves the
                      extracellular region from over 100 substrates, including
                      Notch, amyloid precursor protein, cadherins, growth factors
                      and chemokines. ADAM10 was recently proposed to function as
                      six distinct scissors with different substrates, depending
                      on its association with one of six regulatory tetraspanins,
                      termed TspanC8s. However, it remains unclear whether ADAM10
                      function is critically dependent on a TspanC8 partner. To
                      address this, we generated the first monoclonal antibodies
                      to Tspan15 as a model TspanC8. These were used to show that
                      ADAM10 is the principal Tspan15-interacting protein, that
                      Tspan15 expression requires ADAM10 in cell lines and primary
                      cells, and that a synthetic ADAM10/Tspan15 fusion protein is
                      a functional scissor. Together these findings suggest that
                      ADAM10 exists as an ADAM10/TspanC8 scissor complex.},
      cin          = {AG Lichtenthaler},
      cid          = {I:(DE-2719)1110006},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342) / 352
                      - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF3-342 / G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)32},
      url          = {https://pub.dzne.de/record/248112},
}