Journal Article

DZNE-2023-00320

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Multidomain cognitive training increases physical activity in people with Parkinson's disease with mild cognitive impairment.

Bode, M. (First author)DZNE* ; Sulzer, P.DZNE* ; Schulte, C.DZNE* ; Becker, S.DZNE* ; Brockmann, K.DZNE* ; Elben, S. ; Folkerts, A.-K. ; Ophey, A. ; Schlenstedt, C. ; Witt, K. ; Wojtecki, L. ; Evers, J. ; Maetzler, W.Extern* ; Kalbe, E. ; Liepelt-Scarfone, I. (Last author)DZNE*

2023
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.parkreldis.2023.105330

Abstract: Cognitive impairment in Parkinson's disease (PD), especially in patients with mild cognitive impairment (PD-MCI), coincides with less physical activity. Cognitive trainings (CT) have been found to promote laboratory environment-based movement. Knowledge about their effect in natural home-based environment, reflecting everyday function, is sparse. This explorative study investigated short-term effects of CT on physical activity assessed by home-based accelerometry, and its relation to change of cognitive function over time and non-cognitive outcomes in patients with PD-MCI. Cognitive and non-cognitive correlates of movement parameters at pretest were evaluated as well.Eighteen patients with PD-MCI of the TrainParC study were analyzed. Those patients received either a 6-week multidomain group CT or physical training (PT). Physical activity and sedentary behavior were assessed with wearable accelerometers worn up to seven days pre- and post-training.Patients in the CT group displayed significantly greater increases in active periods after training than patients assigned to PT. In the CT group, increases in executive functioning were associated with increases in active periods and decreases in active mean bout length after training. At pretest, reduced working memory correlated with longer sedentary mean bout length, and impairment in activities of daily living (ADL) correlated with a higher number of sedentary periods.Study data revealed that CT can increase physical activity in patients with PD-MCI, possibly due to effects on executive functions, which needs further investigation in larger sample sizes. Lower working memory performance and ADL impairment might be associated with a more inactive lifestyle in patients with PD-MCI.

Keyword(s): Humans (MeSH) ; Parkinson Disease (MeSH) ; Activities of Daily Living (MeSH) ; Cognitive Training (MeSH) ; Neuropsychological Tests (MeSH) ; Cognitive Dysfunction: psychology (MeSH) ; Exercise (MeSH) ; ADL ; Accelerometry ; Cognition therapy ; Cognitive therapy ; Home-based ; Mild cognitive impairment ; Movement ; Natural environment ; Parkinson's disease ; Physical activity ; Sedentary behavior ; Wearable

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Contributing Institute(s):

1. Parkinson Genetics (AG Gasser)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2023

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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