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000256460 041__ $$aEnglish
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000256460 1001_ $$0P:(DE-2719)9000736$$aSansevrino, Roberto$$b0$$eFirst author$$udzne
000256460 245__ $$aCondensate biology of synaptic vesicle clusters.
000256460 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2023
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000256460 520__ $$aNeuronal communication crucially relies on exocytosis of neurotransmitters from synaptic vesicles (SVs) which are clustered at synapses. To ensure reliable neurotransmitter release, synapses need to maintain an adequate pool of SVs at all times. Decades of research have established that SVs are clustered by synapsin 1, an abundant SV-associated phosphoprotein. The classical view postulates that SVs are crosslinked in a scaffold of protein-protein interactions between synapsins and their binding partners. Recent studies have shown that synapsins cluster SVs via liquid-liquid phase separation (LLPS), thus providing a new framework for the organization of the synapse. We discuss the evidence for phase separation of SVs, emphasizing emerging questions related to its regulation, specificity, and reversibility.
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000256460 650_2 $$2MeSH$$aHumans
000256460 650_2 $$2MeSH$$aSynaptic Vesicles: metabolism
000256460 650_2 $$2MeSH$$aSynapsins: metabolism
000256460 650_2 $$2MeSH$$aSynapses: metabolism
000256460 650_2 $$2MeSH$$aSynaptic Transmission: physiology
000256460 650_2 $$2MeSH$$aBiology
000256460 650_7 $$2Other$$aliquid–liquid phase separation
000256460 650_7 $$2Other$$aliquid–liquid phase separation
000256460 650_7 $$2Other$$aneurotransmission
000256460 650_7 $$2Other$$aphosphorylation
000256460 650_7 $$2Other$$asynapse
000256460 650_7 $$2Other$$asynapsins
000256460 650_7 $$2Other$$aα-synuclein
000256460 650_7 $$2Other$$aα-synuclein
000256460 650_7 $$2NLM Chemicals$$aSynapsins
000256460 7001_ $$0P:(DE-2719)9000582$$aHoffmann, Christian$$b1$$udzne
000256460 7001_ $$0P:(DE-2719)9000670$$aMilovanovic, Dragomir$$b2$$eLast author$$udzne
000256460 773__ $$0PERI:(DE-600)2011000-5$$a10.1016/j.tins.2023.01.001$$gp. S0166223623000152$$n4$$p293-306$$tTrends in neurosciences$$v46$$x0378-5912$$y2023
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