Journal Article (Review Article)

DZNE-2023-00322

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Condensate biology of synaptic vesicle clusters.

Sansevrino, R. (First author)DZNE* ; Hoffmann, C.DZNE* ; Milovanovic, D. (Last author)DZNE*

2023
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.tins.2023.01.001

Abstract: Neuronal communication crucially relies on exocytosis of neurotransmitters from synaptic vesicles (SVs) which are clustered at synapses. To ensure reliable neurotransmitter release, synapses need to maintain an adequate pool of SVs at all times. Decades of research have established that SVs are clustered by synapsin 1, an abundant SV-associated phosphoprotein. The classical view postulates that SVs are crosslinked in a scaffold of protein-protein interactions between synapsins and their binding partners. Recent studies have shown that synapsins cluster SVs via liquid-liquid phase separation (LLPS), thus providing a new framework for the organization of the synapse. We discuss the evidence for phase separation of SVs, emphasizing emerging questions related to its regulation, specificity, and reversibility.

Keyword(s): Humans (MeSH) ; Synaptic Vesicles: metabolism (MeSH) ; Synapsins: metabolism (MeSH) ; Synapses: metabolism (MeSH) ; Synaptic Transmission: physiology (MeSH) ; Biology (MeSH) ; liquid–liquid phase separation ; liquid–liquid phase separation ; neurotransmission ; phosphorylation ; synapse ; synapsins ; α-synuclein ; α-synuclein ; Synapsins

Note: CC BY-NC-ND

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Contributing Institute(s):

1. Molecular Neurobiology (AG Milovanovic)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)

Appears in the scientific report 2023

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