TY  - JOUR
AU  - Sansevrino, Roberto
AU  - Hoffmann, Christian
AU  - Milovanovic, Dragomir
TI  - Condensate biology of synaptic vesicle clusters.
JO  - Trends in neurosciences
VL  - 46
IS  - 4
SN  - 0378-5912
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DZNE-2023-00322
SP  - 293-306
PY  - 2023
N1  - CC BY-NC-ND
AB  - Neuronal communication crucially relies on exocytosis of neurotransmitters from synaptic vesicles (SVs) which are clustered at synapses. To ensure reliable neurotransmitter release, synapses need to maintain an adequate pool of SVs at all times. Decades of research have established that SVs are clustered by synapsin 1, an abundant SV-associated phosphoprotein. The classical view postulates that SVs are crosslinked in a scaffold of protein-protein interactions between synapsins and their binding partners. Recent studies have shown that synapsins cluster SVs via liquid-liquid phase separation (LLPS), thus providing a new framework for the organization of the synapse. We discuss the evidence for phase separation of SVs, emphasizing emerging questions related to its regulation, specificity, and reversibility.
KW  - Humans
KW  - Synaptic Vesicles: metabolism
KW  - Synapsins: metabolism
KW  - Synapses: metabolism
KW  - Synaptic Transmission: physiology
KW  - Biology
KW  - liquid–liquid phase separation (Other)
KW  - liquid–liquid phase separation (Other)
KW  - neurotransmission (Other)
KW  - phosphorylation (Other)
KW  - synapse (Other)
KW  - synapsins (Other)
KW  - α-synuclein (Other)
KW  - α-synuclein (Other)
KW  - Synapsins (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:36725404
DO  - DOI:10.1016/j.tins.2023.01.001
UR  - https://pub.dzne.de/record/256460
ER  -