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@ARTICLE{Sansevrino:256460,
      author       = {Sansevrino, Roberto and Hoffmann, Christian and
                      Milovanovic, Dragomir},
      title        = {{C}ondensate biology of synaptic vesicle clusters.},
      journal      = {Trends in neurosciences},
      volume       = {46},
      number       = {4},
      issn         = {0378-5912},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2023-00322},
      pages        = {293-306},
      year         = {2023},
      note         = {CC BY-NC-ND},
      abstract     = {Neuronal communication crucially relies on exocytosis of
                      neurotransmitters from synaptic vesicles (SVs) which are
                      clustered at synapses. To ensure reliable neurotransmitter
                      release, synapses need to maintain an adequate pool of SVs
                      at all times. Decades of research have established that SVs
                      are clustered by synapsin 1, an abundant SV-associated
                      phosphoprotein. The classical view postulates that SVs are
                      crosslinked in a scaffold of protein-protein interactions
                      between synapsins and their binding partners. Recent studies
                      have shown that synapsins cluster SVs via liquid-liquid
                      phase separation (LLPS), thus providing a new framework for
                      the organization of the synapse. We discuss the evidence for
                      phase separation of SVs, emphasizing emerging questions
                      related to its regulation, specificity, and reversibility.},
      subtyp        = {Review Article},
      keywords     = {Humans / Synaptic Vesicles: metabolism / Synapsins:
                      metabolism / Synapses: metabolism / Synaptic Transmission:
                      physiology / Biology / liquid–liquid phase separation
                      (Other) / liquid–liquid phase separation (Other) /
                      neurotransmission (Other) / phosphorylation (Other) /
                      synapse (Other) / synapsins (Other) / α-synuclein (Other) /
                      α-synuclein (Other) / Synapsins (NLM Chemicals)},
      cin          = {AG Milovanovic},
      ddc          = {610},
      cid          = {I:(DE-2719)1813002},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36725404},
      doi          = {10.1016/j.tins.2023.01.001},
      url          = {https://pub.dzne.de/record/256460},
}