Home > Publications Database > Condensate biology of synaptic vesicle clusters. > print

001     256460
005     20240112171743.0
024 7 _ |a 10.1016/j.tins.2023.01.001
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024 7 _ |a pmid:36725404
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024 7 _ |a 0378-5912
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024 7 _ |a 0166-2236
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024 7 _ |a 1878-108X
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037 _ _ |a DZNE-2023-00322
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Sansevrino, Roberto
|0 P:(DE-2719)9000736
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245 _ _ |a Condensate biology of synaptic vesicle clusters.
260 _ _ |a Amsterdam [u.a.]
|c 2023
|b Elsevier Science
336 7 _ |a article
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336 7 _ |a ARTICLE
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500 _ _ |a CC BY-NC-ND
520 _ _ |a Neuronal communication crucially relies on exocytosis of neurotransmitters from synaptic vesicles (SVs) which are clustered at synapses. To ensure reliable neurotransmitter release, synapses need to maintain an adequate pool of SVs at all times. Decades of research have established that SVs are clustered by synapsin 1, an abundant SV-associated phosphoprotein. The classical view postulates that SVs are crosslinked in a scaffold of protein-protein interactions between synapsins and their binding partners. Recent studies have shown that synapsins cluster SVs via liquid-liquid phase separation (LLPS), thus providing a new framework for the organization of the synapse. We discuss the evidence for phase separation of SVs, emphasizing emerging questions related to its regulation, specificity, and reversibility.
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650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Synaptic Vesicles: metabolism
|2 MeSH
650 _ 2 |a Synapsins: metabolism
|2 MeSH
650 _ 2 |a Synapses: metabolism
|2 MeSH
650 _ 2 |a Synaptic Transmission: physiology
|2 MeSH
650 _ 2 |a Biology
|2 MeSH
650 _ 7 |a liquid–liquid phase separation
|2 Other
650 _ 7 |a liquid–liquid phase separation
|2 Other
650 _ 7 |a neurotransmission
|2 Other
650 _ 7 |a phosphorylation
|2 Other
650 _ 7 |a synapse
|2 Other
650 _ 7 |a synapsins
|2 Other
650 _ 7 |a α-synuclein
|2 Other
650 _ 7 |a α-synuclein
|2 Other
650 _ 7 |a Synapsins
|2 NLM Chemicals
700 1 _ |a Hoffmann, Christian
|0 P:(DE-2719)9000582
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700 1 _ |a Milovanovic, Dragomir
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773 _ _ |a 10.1016/j.tins.2023.01.001
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|t Trends in neurosciences
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856 4 _ |y OpenAccess
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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