TY  - JOUR
AU  - Pohlig, Florian
AU  - Wittek, Michael
AU  - VON Thaden, Anne
AU  - Lenze, Ulrich
AU  - Glowalla, Claudio
AU  - Minzlaff, Philipp
AU  - Burgkart, Rainer
AU  - Prodinger, Peter Michael
TI  - Biomechanical Properties of Repair Cartilage Tissue Are Superior Following Microdrilling Compared to Microfracturing in Critical Size Cartilage Defects.
JO  - In vivo
VL  - 37
IS  - 2
SN  - 0258-851x
CY  - Kapandriti, Attiki
PB  - IIAR
M1  - DZNE-2023-00338
SP  - 565 - 573
PY  - 2023
N1  - CC BY-NC-ND
AB  - Common surgical treatment options for large focal chondral defects (FCDs) in the knee include microfracturing (MFX) and microdrilling (DRL). Despite numerous studies addressing MFX and DRL of FDCs, no in vivo study has focused on biomechanical analysis of repair cartilage tissue in critical size FCDs with different amounts of holes and penetration depths.Two round FCDs (d=6 mm) were created on the medial femoral condyle in 33 adult merino sheep. All 66 defects were randomly assigned to 1 control or 4 different study groups: 1) MFX1, 3 holes, 2 mm depth; 2) MFX2, 3 holes, 4 mm depth; 3) DRL1, 3 holes, 4 mm depth; and 4) DRL2, 6 holes, 4 mm depth. Animals were followed up for 1 year. Following euthanasia, quantitative optical analysis of defect filling was performed. Biomechanical properties were analysed with microindentation and calculation of the elastic modulus.Quantitative assessment of defect filling showed significantly better results in all treatment groups compared to untreated FCDs in the control group (p<0.001), with the best results for DRL2 (84.2
KW  - Animals
KW  - Control Groups
KW  - Cartilage
KW  - DRL (Other)
KW  - FCD (Other)
KW  - Knee (Other)
KW  - MFX (Other)
KW  - cartilage (Other)
KW  - defect (Other)
KW  - drilling (Other)
KW  - focal chondral defect (Other)
KW  - microfracturing (Other)
KW  - regeneration (Other)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC10026649
C6  - pmid:36881065
DO  - DOI:10.21873/invivo.13115
UR  - https://pub.dzne.de/record/256514
ER  -