Home > Publications Database > Biomechanical Properties of Repair Cartilage Tissue Are Superior Following Microdrilling Compared to Microfracturing in Critical Size Cartilage Defects. > print

001     256514
005     20231004134629.0
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024 7 _ |a 10.21873/invivo.13115
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037 _ _ |a DZNE-2023-00338
041 _ _ |a English
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100 1 _ |a Pohlig, Florian
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245 _ _ |a Biomechanical Properties of Repair Cartilage Tissue Are Superior Following Microdrilling Compared to Microfracturing in Critical Size Cartilage Defects.
260 _ _ |a Kapandriti, Attiki
|c 2023
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336 7 _ |a article
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520 _ _ |a Common surgical treatment options for large focal chondral defects (FCDs) in the knee include microfracturing (MFX) and microdrilling (DRL). Despite numerous studies addressing MFX and DRL of FDCs, no in vivo study has focused on biomechanical analysis of repair cartilage tissue in critical size FCDs with different amounts of holes and penetration depths.Two round FCDs (d=6 mm) were created on the medial femoral condyle in 33 adult merino sheep. All 66 defects were randomly assigned to 1 control or 4 different study groups: 1) MFX1, 3 holes, 2 mm depth; 2) MFX2, 3 holes, 4 mm depth; 3) DRL1, 3 holes, 4 mm depth; and 4) DRL2, 6 holes, 4 mm depth. Animals were followed up for 1 year. Following euthanasia, quantitative optical analysis of defect filling was performed. Biomechanical properties were analysed with microindentation and calculation of the elastic modulus.Quantitative assessment of defect filling showed significantly better results in all treatment groups compared to untreated FCDs in the control group (p<0.001), with the best results for DRL2 (84.2% filling). The elastic modulus of repair cartilage tissue in the DRL1 and DRL2 groups was comparable to the adjacent native hyaline cartilage, while significantly inferior results were identified in both MFX groups (MFX1: p=0.002; MFX2: p<0.001).More defect filling and better biomechanical properties of the repair cartilage tissue were identified for DRL compared to MFX, with the best results for 6 holes and 4 mm of penetration depth. These findings are in contrast to the current clinical practice with MFX as the gold standard and suggest a clinical return to DRL.
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650 _ 7 |a DRL
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650 _ 7 |a FCD
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650 _ 7 |a Knee
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650 _ 7 |a MFX
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650 _ 7 |a cartilage
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650 _ 7 |a defect
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650 _ 7 |a drilling
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650 _ 7 |a focal chondral defect
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650 _ 7 |a microfracturing
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650 _ 7 |a regeneration
|2 Other
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Control Groups
|2 MeSH
650 _ 2 |a Cartilage
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700 1 _ |a Wittek, Michael
|b 1
700 1 _ |a VON Thaden, Anne
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700 1 _ |a Lenze, Ulrich
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700 1 _ |a Glowalla, Claudio
|b 4
700 1 _ |a Minzlaff, Philipp
|b 5
700 1 _ |a Burgkart, Rainer
|b 6
700 1 _ |a Prodinger, Peter Michael
|b 7
773 _ _ |a 10.21873/invivo.13115
|g Vol. 37, no. 2, p. 565 - 573
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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