TY  - JOUR
AU  - Antignano, Ignazio
AU  - Liu, Yingxiao
AU  - Offermann, Nina
AU  - Capasso, Melania
TI  - Aging microglia
JO  - Cellular and molecular life sciences
VL  - 80
IS  - 5
SN  - 1420-682X
CY  - Cham (ZG)
PB  - Springer International Publishing AG
M1  - DZNE-2023-00478
SP  - 126
PY  - 2023
AB  - Microglia are the tissue-resident macrophage population of the brain, specialized in supporting the CNS environment and protecting it from endogenous and exogenous insults. Nonetheless, their function declines with age, in ways that remain to be fully elucidated. Given the critical role played by microglia in neurodegenerative diseases, a better understanding of the aging microglia phenotype is an essential prerequisite in designing better preventive and therapeutic strategies. In this review, we discuss the most recent literature on microglia in aging, comparing findings in rodent models and human subjects.
KW  - Cellular Senescence
KW  - Humans
KW  - Microglia
KW  - Aging
KW  - Brain
KW  - Neurodegenerative Diseases
KW  - Animals
KW  - Oxidative Stress
KW  - Signal Transduction
KW  - Monocytes
KW  - Brain-Gut Axis
KW  - Aging (Other)
KW  - Human microglia (Other)
KW  - Microglia (Other)
KW  - Neuroinflammation (Other)
KW  - RNAseq (Other)
KW  - Senescence (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37081238
C2  - pmc:PMC10119228
DO  - DOI:10.1007/s00018-023-04775-y
UR  - https://pub.dzne.de/record/257681
ER  -