Journal Article (Review Article)

DZNE-2023-00478

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Aging microglia

Antignano, I. (First author)DZNE* ; Liu, Y.DZNE* ; Offermann, N.DZNE* ; Capasso, M. (Last author)DZNE*

2023
Springer International Publishing AG Cham (ZG)

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Please use a persistent id in citations: doi:10.1007/s00018-023-04775-y

Abstract: Microglia are the tissue-resident macrophage population of the brain, specialized in supporting the CNS environment and protecting it from endogenous and exogenous insults. Nonetheless, their function declines with age, in ways that remain to be fully elucidated. Given the critical role played by microglia in neurodegenerative diseases, a better understanding of the aging microglia phenotype is an essential prerequisite in designing better preventive and therapeutic strategies. In this review, we discuss the most recent literature on microglia in aging, comparing findings in rodent models and human subjects.

Keyword(s): Cellular Senescence (MeSH) ; Humans (MeSH) ; Microglia (MeSH) ; Aging (MeSH) ; Brain (MeSH) ; Neurodegenerative Diseases (MeSH) ; Animals (MeSH) ; Oxidative Stress (MeSH) ; Signal Transduction (MeSH) ; Monocytes (MeSH) ; Brain-Gut Axis (MeSH) ; Aging ; Human microglia ; Microglia ; Neuroinflammation ; RNAseq ; Senescence

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Contributing Institute(s):

1. Immune Regulation (AG Capasso)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)

Appears in the scientific report 2023

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Database coverage:
; ; ; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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