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001     257681
005     20240611120549.0
024 7 _ |a 10.1007/s00018-023-04775-y
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100 1 _ |a Antignano, Ignazio
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245 _ _ |a Aging microglia
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520 _ _ |a Microglia are the tissue-resident macrophage population of the brain, specialized in supporting the CNS environment and protecting it from endogenous and exogenous insults. Nonetheless, their function declines with age, in ways that remain to be fully elucidated. Given the critical role played by microglia in neurodegenerative diseases, a better understanding of the aging microglia phenotype is an essential prerequisite in designing better preventive and therapeutic strategies. In this review, we discuss the most recent literature on microglia in aging, comparing findings in rodent models and human subjects.
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650 _ 7 |a Aging
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650 _ 7 |a Human microglia
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650 _ 7 |a Microglia
|2 Other
650 _ 7 |a Neuroinflammation
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650 _ 7 |a RNAseq
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650 _ 7 |a Senescence
|2 Other
650 _ 2 |a Cellular Senescence
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Microglia
|2 MeSH
650 _ 2 |a Aging
|2 MeSH
650 _ 2 |a Brain
|2 MeSH
650 _ 2 |a Neurodegenerative Diseases
|2 MeSH
650 _ 2 |a Animals
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650 _ 2 |a Oxidative Stress
|2 MeSH
650 _ 2 |a Signal Transduction
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650 _ 2 |a Monocytes
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650 _ 2 |a Brain-Gut Axis
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700 1 _ |a Liu, Yingxiao
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700 1 _ |a Offermann, Nina
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700 1 _ |a Capasso, Melania
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773 _ _ |a 10.1007/s00018-023-04775-y
|g Vol. 80, no. 5, p. 126
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|t Cellular and molecular life sciences
|v 80
|y 2023
|x 1420-682X
856 4 _ |u https://pub.dzne.de/record/257681/files/10.1007s00018-023-04775-y.pdf
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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