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000257687 0247_ $$2doi$$a10.1007/s00702-023-02634-5
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000257687 0247_ $$2ISSN$$a0022-3026
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000257687 041__ $$aEnglish
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000257687 1001_ $$00000-0002-3833-9822$$aSchröter, Nils$$b0
000257687 245__ $$aSignificance of clinical symptoms and red flags in early differential diagnosis of Parkinson's disease and atypical Parkinsonian syndromes.
000257687 260__ $$aWien [u.a.]$$bSpringer$$c2023
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000257687 520__ $$aThe clinical presentation of Parkinson's disease and atypical Parkinsonian syndromes is often heterogeneous. Additional diagnostic procedures including brain imaging and biomarker analyses can help to appreciate the various syndromes, but a precise clinical evaluation and differentiation is always necessary. To better assess the relevance of distinct clinical symptoms that arose within 1 year of disease manifestation and evaluate their indicative potential for an atypical Parkinsonian syndrome, we conducted a modified Delphi panel with seven movement disorder specialists. Five different topics with several clinical symptom items were discussed and consensus criteria were tested. This resulted in distinct symptom patterns for each atypical Parkinsonian syndrome showing the multitude of clinical involvement in each neurodegenerative disease. Strongly discriminating clinical signs were few and levels of indication were variable. A prospective validation of the assessments made is needed. This demonstrates that both clinical evaluation and elaborate additional diagnostic procedures are needed to achieve a high diagnostic standard.
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000257687 650_7 $$2Other$$aAtypical Parkinson syndromes
000257687 650_7 $$2Other$$aCBS
000257687 650_7 $$2Other$$aDLB
000257687 650_7 $$2Other$$aMSA
000257687 650_7 $$2Other$$aPSP
000257687 650_2 $$2MeSH$$aHumans
000257687 650_2 $$2MeSH$$aParkinson Disease: diagnosis
000257687 650_2 $$2MeSH$$aDiagnosis, Differential
000257687 650_2 $$2MeSH$$aEmblems and Insignia
000257687 650_2 $$2MeSH$$aSupranuclear Palsy, Progressive: diagnosis
000257687 650_2 $$2MeSH$$aParkinsonian Disorders: diagnosis
000257687 650_2 $$2MeSH$$aMultiple System Atrophy: diagnosis
000257687 7001_ $$avan Eimeren, Thilo$$b1
000257687 7001_ $$aClassen, Joseph$$b2
000257687 7001_ $$0P:(DE-2719)2811659$$aLevin, Johannes$$b3$$udzne
000257687 7001_ $$aRedecker, Christoph$$b4
000257687 7001_ $$aWolz, Martin$$b5
000257687 7001_ $$aTönges, Lars$$b6
000257687 773__ $$0PERI:(DE-600)1481655-6$$a10.1007/s00702-023-02634-5$$gVol. 130, no. 6, p. 839 - 846$$n6$$p839-846$$tJournal of neural transmission$$v130$$x0375-9245$$y2023
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