Journal Article

DZNE-2023-00484

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Significance of clinical symptoms and red flags in early differential diagnosis of Parkinson's disease and atypical Parkinsonian syndromes.

Schröter, N. ; van Eimeren, T. ; Classen, J. ; Levin, J.DZNE* ; Redecker, C. ; Wolz, M. ; Tönges, L.

2023
Springer Wien [u.a.]

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Please use a persistent id in citations: doi:10.1007/s00702-023-02634-5

Abstract: The clinical presentation of Parkinson's disease and atypical Parkinsonian syndromes is often heterogeneous. Additional diagnostic procedures including brain imaging and biomarker analyses can help to appreciate the various syndromes, but a precise clinical evaluation and differentiation is always necessary. To better assess the relevance of distinct clinical symptoms that arose within 1 year of disease manifestation and evaluate their indicative potential for an atypical Parkinsonian syndrome, we conducted a modified Delphi panel with seven movement disorder specialists. Five different topics with several clinical symptom items were discussed and consensus criteria were tested. This resulted in distinct symptom patterns for each atypical Parkinsonian syndrome showing the multitude of clinical involvement in each neurodegenerative disease. Strongly discriminating clinical signs were few and levels of indication were variable. A prospective validation of the assessments made is needed. This demonstrates that both clinical evaluation and elaborate additional diagnostic procedures are needed to achieve a high diagnostic standard.

Keyword(s): Humans (MeSH) ; Parkinson Disease: diagnosis (MeSH) ; Diagnosis, Differential (MeSH) ; Emblems and Insignia (MeSH) ; Supranuclear Palsy, Progressive: diagnosis (MeSH) ; Parkinsonian Disorders: diagnosis (MeSH) ; Multiple System Atrophy: diagnosis (MeSH) ; Atypical Parkinson syndromes ; CBS ; DLB ; MSA ; PSP

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Contributing Institute(s):

1. Clinical Dementia Research München Levin (Clinical Dementia Research München ; AG Levin)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2023

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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