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@ARTICLE{Schrter:257687,
      author       = {Schröter, Nils and van Eimeren, Thilo and Classen, Joseph
                      and Levin, Johannes and Redecker, Christoph and Wolz, Martin
                      and Tönges, Lars},
      title        = {{S}ignificance of clinical symptoms and red flags in early
                      differential diagnosis of {P}arkinson's disease and atypical
                      {P}arkinsonian syndromes.},
      journal      = {Journal of neural transmission},
      volume       = {130},
      number       = {6},
      issn         = {0375-9245},
      address      = {Wien [u.a.]},
      publisher    = {Springer},
      reportid     = {DZNE-2023-00484},
      pages        = {839-846},
      year         = {2023},
      abstract     = {The clinical presentation of Parkinson's disease and
                      atypical Parkinsonian syndromes is often heterogeneous.
                      Additional diagnostic procedures including brain imaging and
                      biomarker analyses can help to appreciate the various
                      syndromes, but a precise clinical evaluation and
                      differentiation is always necessary. To better assess the
                      relevance of distinct clinical symptoms that arose within 1
                      year of disease manifestation and evaluate their indicative
                      potential for an atypical Parkinsonian syndrome, we
                      conducted a modified Delphi panel with seven movement
                      disorder specialists. Five different topics with several
                      clinical symptom items were discussed and consensus criteria
                      were tested. This resulted in distinct symptom patterns for
                      each atypical Parkinsonian syndrome showing the multitude of
                      clinical involvement in each neurodegenerative disease.
                      Strongly discriminating clinical signs were few and levels
                      of indication were variable. A prospective validation of the
                      assessments made is needed. This demonstrates that both
                      clinical evaluation and elaborate additional diagnostic
                      procedures are needed to achieve a high diagnostic
                      standard.},
      keywords     = {Humans / Parkinson Disease: diagnosis / Diagnosis,
                      Differential / Emblems and Insignia / Supranuclear Palsy,
                      Progressive: diagnosis / Parkinsonian Disorders: diagnosis /
                      Multiple System Atrophy: diagnosis / Atypical Parkinson
                      syndromes (Other) / CBS (Other) / DLB (Other) / MSA (Other)
                      / PSP (Other)},
      cin          = {Clinical Dementia Research München ; AG Levin},
      ddc          = {610},
      cid          = {I:(DE-2719)1111016},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC10199882},
      pubmed       = {pmid:37046147},
      doi          = {10.1007/s00702-023-02634-5},
      url          = {https://pub.dzne.de/record/257687},
}