Home > Publications Database > Significance of clinical symptoms and red flags in early differential diagnosis of Parkinson's disease and atypical Parkinsonian syndromes. > print

001     257687
005     20231120155341.0
024 7 _ |a pmc:PMC10199882
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024 7 _ |a 10.1007/s00702-023-02634-5
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024 7 _ |a pmid:37046147
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024 7 _ |a 0375-9245
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024 7 _ |a 0022-3026
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024 7 _ |a 1435-1463
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037 _ _ |a DZNE-2023-00484
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Schröter, Nils
|0 0000-0002-3833-9822
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245 _ _ |a Significance of clinical symptoms and red flags in early differential diagnosis of Parkinson's disease and atypical Parkinsonian syndromes.
260 _ _ |a Wien [u.a.]
|c 2023
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520 _ _ |a The clinical presentation of Parkinson's disease and atypical Parkinsonian syndromes is often heterogeneous. Additional diagnostic procedures including brain imaging and biomarker analyses can help to appreciate the various syndromes, but a precise clinical evaluation and differentiation is always necessary. To better assess the relevance of distinct clinical symptoms that arose within 1 year of disease manifestation and evaluate their indicative potential for an atypical Parkinsonian syndrome, we conducted a modified Delphi panel with seven movement disorder specialists. Five different topics with several clinical symptom items were discussed and consensus criteria were tested. This resulted in distinct symptom patterns for each atypical Parkinsonian syndrome showing the multitude of clinical involvement in each neurodegenerative disease. Strongly discriminating clinical signs were few and levels of indication were variable. A prospective validation of the assessments made is needed. This demonstrates that both clinical evaluation and elaborate additional diagnostic procedures are needed to achieve a high diagnostic standard.
536 _ _ |a 353 - Clinical and Health Care Research (POF4-353)
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650 _ 7 |a Atypical Parkinson syndromes
|2 Other
650 _ 7 |a CBS
|2 Other
650 _ 7 |a DLB
|2 Other
650 _ 7 |a MSA
|2 Other
650 _ 7 |a PSP
|2 Other
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Parkinson Disease: diagnosis
|2 MeSH
650 _ 2 |a Diagnosis, Differential
|2 MeSH
650 _ 2 |a Emblems and Insignia
|2 MeSH
650 _ 2 |a Supranuclear Palsy, Progressive: diagnosis
|2 MeSH
650 _ 2 |a Parkinsonian Disorders: diagnosis
|2 MeSH
650 _ 2 |a Multiple System Atrophy: diagnosis
|2 MeSH
700 1 _ |a van Eimeren, Thilo
|b 1
700 1 _ |a Classen, Joseph
|b 2
700 1 _ |a Levin, Johannes
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700 1 _ |a Redecker, Christoph
|b 4
700 1 _ |a Wolz, Martin
|b 5
700 1 _ |a Tönges, Lars
|b 6
773 _ _ |a 10.1007/s00702-023-02634-5
|g Vol. 130, no. 6, p. 839 - 846
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|n 6
|p 839-846
|t Journal of neural transmission
|v 130
|y 2023
|x 0375-9245
856 4 _ |u https://pub.dzne.de/record/257687/files/DZNE-2023-00484.pdf
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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