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@ARTICLE{Vinopal:257692,
      author       = {Vinopal, Stanislav and Dupraz, Sebastian and Alfadil, Eissa
                      and Pietralla, Thorben and Bendre, Shweta and Stiess,
                      Michael and Falk, Sven and Camargo Ortega, Germán and
                      Maghelli, Nicola and Tolić, Iva M and Smejkal, Jiří and
                      Götz, Magdalena and Bradke, Frank},
      title        = {{C}entrosomal microtubule nucleation regulates radial
                      migration of projection neurons independently of
                      polarization in the developing brain.},
      journal      = {Neuron},
      volume       = {111},
      number       = {8},
      issn         = {0896-6273},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {DZNE-2023-00489},
      pages        = {1241 - 1263.e16},
      year         = {2023},
      abstract     = {Cortical projection neurons polarize and form an axon while
                      migrating radially. Even though these dynamic processes are
                      closely interwoven, they are regulated separately-the
                      neurons terminate their migration when reaching their
                      destination, the cortical plate, but continue to grow their
                      axons. Here, we show that in rodents, the centrosome
                      distinguishes these processes. Newly developed molecular
                      tools modulating centrosomal microtubule nucleation combined
                      with in vivo imaging uncovered that dysregulation of
                      centrosomal microtubule nucleation abrogated radial
                      migration without affecting axon formation. Tightly
                      regulated centrosomal microtubule nucleation was required
                      for periodic formation of the cytoplasmic dilation at the
                      leading process, which is essential for radial migration.
                      The microtubule nucleating factor γ-tubulin decreased at
                      neuronal centrosomes during the migratory phase. As distinct
                      microtubule networks drive neuronal polarization and radial
                      migration, this provides insight into how neuronal migratory
                      defects occur without largely affecting axonal tracts in
                      human developmental cortical dysgeneses, caused by mutations
                      in γ-tubulin.},
      keywords     = {Humans / Tubulin: metabolism / Neurons: physiology / Axons:
                      metabolism / Microtubules: metabolism / Centrosome / Brain:
                      metabolism / axon formation (Other) / centrosome (Other) /
                      microtubule (Other) / neuronal polarity (Other) / radial
                      migration (Other) / Tubulin (NLM Chemicals)},
      cin          = {AG Bradke},
      ddc          = {610},
      cid          = {I:(DE-2719)1013002},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36796357},
      doi          = {10.1016/j.neuron.2023.01.020},
      url          = {https://pub.dzne.de/record/257692},
}