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000257695 0247_ $$2doi$$a10.1016/j.devcel.2013.09.002
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000257695 0247_ $$2ISSN$$a1878-1551
000257695 037__ $$aDZNE-2023-00492
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000257695 1001_ $$0P:(DE-2719)2814117$$aToda, Tomohisa$$b0$$udzne
000257695 245__ $$aBirth regulates the initiation of sensory map formation through serotonin signaling.
000257695 260__ $$aNew York, NY$$bElsevier$$c2013
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000257695 520__ $$aAlthough the mechanisms underlying the spatial pattern formation of sensory maps have been extensively investigated, those triggering sensory map formation during development are largely unknown. Here we show that the birth of pups instructively and selectively regulates the initiation of barrel formation in the somatosensory cortex by reducing serotonin concentration. We found that preterm birth accelerated barrel formation, whereas it did not affect either barreloid formation or barrel structural plasticity. We also found that serotonin was selectively reduced soon after birth and that the reduction of serotonin was triggered by birth. The reduction of serotonin was necessary and sufficient for the effect of birth on barrel formation. Interestingly, the regulatory mechanisms described here were also found to regulate eye-specific segregation in the visual system, suggesting that they are utilized in various brain regions. Our results shed light on roles of birth and serotonin in sensory map formation.
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000257695 650_7 $$0333DO1RDJY$$2NLM Chemicals$$aSerotonin
000257695 650_2 $$2MeSH$$aAnimals
000257695 650_2 $$2MeSH$$aFemale
000257695 650_2 $$2MeSH$$aMice
000257695 650_2 $$2MeSH$$aMice, Inbred C57BL
000257695 650_2 $$2MeSH$$aNeurons, Afferent: metabolism
000257695 650_2 $$2MeSH$$aNeurons, Afferent: physiology
000257695 650_2 $$2MeSH$$aParturition: metabolism
000257695 650_2 $$2MeSH$$aPregnancy
000257695 650_2 $$2MeSH$$aSerotonin: metabolism
000257695 650_2 $$2MeSH$$aSignal Transduction
000257695 650_2 $$2MeSH$$aSomatosensory Cortex: cytology
000257695 650_2 $$2MeSH$$aSomatosensory Cortex: growth & development
000257695 650_2 $$2MeSH$$aSomatosensory Cortex: metabolism
000257695 650_2 $$2MeSH$$aSomatosensory Cortex: physiology
000257695 7001_ $$aHomma, Daigo$$b1
000257695 7001_ $$aTokuoka, Hirofumi$$b2
000257695 7001_ $$aHayakawa, Itaru$$b3
000257695 7001_ $$aSugimoto, Yukihiko$$b4
000257695 7001_ $$aIchinose, Hiroshi$$b5
000257695 7001_ $$aKawasaki, Hiroshi$$b6
000257695 773__ $$0PERI:(DE-600)2053870-4$$a10.1016/j.devcel.2013.09.002$$gVol. 27, no. 1, p. 32 - 46$$n1$$p32 - 46$$tDevelopmental cell$$v27$$x1534-5807$$y2013
000257695 8564_ $$uhttps://pub.dzne.de/record/257695/files/DZNE-2023-00492.pdf
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