Journal Article

DZNE-2023-00492

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Birth regulates the initiation of sensory map formation through serotonin signaling.

Toda, T.Extern* ; Homma, D. ; Tokuoka, H. ; Hayakawa, I. ; Sugimoto, Y. ; Ichinose, H. ; Kawasaki, H.

2013
Elsevier New York, NY

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Please use a persistent id in citations: doi:10.1016/j.devcel.2013.09.002

Abstract: Although the mechanisms underlying the spatial pattern formation of sensory maps have been extensively investigated, those triggering sensory map formation during development are largely unknown. Here we show that the birth of pups instructively and selectively regulates the initiation of barrel formation in the somatosensory cortex by reducing serotonin concentration. We found that preterm birth accelerated barrel formation, whereas it did not affect either barreloid formation or barrel structural plasticity. We also found that serotonin was selectively reduced soon after birth and that the reduction of serotonin was triggered by birth. The reduction of serotonin was necessary and sufficient for the effect of birth on barrel formation. Interestingly, the regulatory mechanisms described here were also found to regulate eye-specific segregation in the visual system, suggesting that they are utilized in various brain regions. Our results shed light on roles of birth and serotonin in sensory map formation.

Keyword(s): Animals (MeSH) ; Female (MeSH) ; Mice (MeSH) ; Mice, Inbred C57BL (MeSH) ; Neurons, Afferent: metabolism (MeSH) ; Neurons, Afferent: physiology (MeSH) ; Parturition: metabolism (MeSH) ; Pregnancy (MeSH) ; Serotonin: metabolism (MeSH) ; Signal Transduction (MeSH) ; Somatosensory Cortex: cytology (MeSH) ; Somatosensory Cortex: growth & development (MeSH) ; Somatosensory Cortex: metabolism (MeSH) ; Somatosensory Cortex: physiology (MeSH) ; Serotonin

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Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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