TY  - JOUR
AU  - Toda, Tomohisa
AU  - Homma, Daigo
AU  - Tokuoka, Hirofumi
AU  - Hayakawa, Itaru
AU  - Sugimoto, Yukihiko
AU  - Ichinose, Hiroshi
AU  - Kawasaki, Hiroshi
TI  - Birth regulates the initiation of sensory map formation through serotonin signaling.
JO  - Developmental cell
VL  - 27
IS  - 1
SN  - 1534-5807
CY  - New York, NY
PB  - Elsevier
M1  - DZNE-2023-00492
SP  - 32 - 46
PY  - 2013
AB  - Although the mechanisms underlying the spatial pattern formation of sensory maps have been extensively investigated, those triggering sensory map formation during development are largely unknown. Here we show that the birth of pups instructively and selectively regulates the initiation of barrel formation in the somatosensory cortex by reducing serotonin concentration. We found that preterm birth accelerated barrel formation, whereas it did not affect either barreloid formation or barrel structural plasticity. We also found that serotonin was selectively reduced soon after birth and that the reduction of serotonin was triggered by birth. The reduction of serotonin was necessary and sufficient for the effect of birth on barrel formation. Interestingly, the regulatory mechanisms described here were also found to regulate eye-specific segregation in the visual system, suggesting that they are utilized in various brain regions. Our results shed light on roles of birth and serotonin in sensory map formation.
KW  - Animals
KW  - Female
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Neurons, Afferent: metabolism
KW  - Neurons, Afferent: physiology
KW  - Parturition: metabolism
KW  - Pregnancy
KW  - Serotonin: metabolism
KW  - Signal Transduction
KW  - Somatosensory Cortex: cytology
KW  - Somatosensory Cortex: growth & development
KW  - Somatosensory Cortex: metabolism
KW  - Somatosensory Cortex: physiology
KW  - Serotonin (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:24135230
DO  - DOI:10.1016/j.devcel.2013.09.002
UR  - https://pub.dzne.de/record/257695
ER  -