Journal Article

DZNE-2023-00521

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A shift in the mechanisms controlling hippocampal engram formation during brain maturation.

Ramsaran, A. I. ; Wang, Y. ; Golbabaei, A. ; Aleshin, S.DZNE* ; de Snoo, M. L. ; Yeung, B. A. ; Rashid, A. J. ; Awasthi, A. ; Lau, J. ; Tran, L. M. ; Ko, S. Y. ; Abegg, A. ; Duan, L. C. ; McKenzie, C. ; Gallucci, J. ; Ahmed, M. ; Kaushik, R.DZNE* ; Dityatev, A.DZNE* ; Josselyn, S. A. ; Frankland, P. W.

2023
Assoc. Washington, DC

This record in other databases:    

Please use a persistent id in citations: doi:10.1126/science.ade6530

Abstract: The ability to form precise, episodic memories develops with age, with young children only able to form gist-like memories that lack precision. The cellular and molecular events in the developing hippocampus that underlie the emergence of precise, episodic-like memory are unclear. In mice, the absence of a competitive neuronal engram allocation process in the immature hippocampus precluded the formation of sparse engrams and precise memories until the fourth postnatal week, when inhibitory circuits in the hippocampus mature. This age-dependent shift in precision of episodic-like memories involved the functional maturation of parvalbumin-expressing interneurons in subfield CA1 through assembly of extracellular perineuronal nets, which is necessary and sufficient for the onset of competitive neuronal allocation, sparse engram formation, and memory precision.

Keyword(s): Mice (MeSH) ; Animals (MeSH) ; Hippocampus: physiology (MeSH) ; Neurons: physiology (MeSH) ; Interneurons (MeSH) ; Memory, Episodic (MeSH) ; Mice, Inbred C57BL (MeSH)

Note: ISSN 1095-9203 not unique: **3 hits**.

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Contributing Institute(s):

1. Molecular Neuroplasticity (AG Dityatev)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)

Appears in the scientific report 2023

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; BIOSIS Previews ; Biological Abstracts ; Chemical Reactions ; Clarivate Analytics Master Journal List ; Current Contents - Agriculture, Biology and Environmental Sciences ; Current Contents - Life Sciences ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 50 ; Index Chemicus ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection ; Zoological Record

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