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000258000 1001_ $$00000-0001-9681-6298$$aRichter, Anni$$b0
000258000 245__ $$aSingle-value scores of memory-related brain activity reflect dissociable neuropsychological and anatomical signatures of neurocognitive aging.
000258000 260__ $$aNew York, NY$$bWiley-Liss$$c2023
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000258000 520__ $$aMemory-related functional magnetic resonance imaging (fMRI) activations show age-related differences across multiple brain regions that can be captured in summary statistics like single-value scores. Recently, we described two single-value scores reflecting deviations from prototypical whole-brain fMRI activity of young adults during novelty processing and successful encoding. Here, we investigate the brain-behavior associations of these scores with age-related neurocognitive changes in 153 healthy middle-aged and older adults. All scores were associated with episodic recall performance. The memory network scores, but not the novelty network scores, additionally correlated with medial temporal gray matter and other neuropsychological measures including flexibility. Our results thus suggest that novelty-network-based fMRI scores show high brain-behavior associations with episodic memory and that encoding-network-based fMRI scores additionally capture individual differences in other aging-related functions. More generally, our results suggest that single-value scores of memory-related fMRI provide a comprehensive measure of individual differences in network dysfunction that may contribute to age-related cognitive decline.
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000258000 650_7 $$2Other$$acognitive aging
000258000 650_7 $$2Other$$aepisodic memory
000258000 650_7 $$2Other$$afMRI
000258000 650_7 $$2Other$$ahippocampus
000258000 650_7 $$2Other$$amemory impairment
000258000 650_7 $$2Other$$asubsequent memory effect
000258000 650_2 $$2MeSH$$aMiddle Aged
000258000 650_2 $$2MeSH$$aYoung Adult
000258000 650_2 $$2MeSH$$aHumans
000258000 650_2 $$2MeSH$$aAged
000258000 650_2 $$2MeSH$$aAging: psychology
000258000 650_2 $$2MeSH$$aBrain: diagnostic imaging
000258000 650_2 $$2MeSH$$aMental Recall
000258000 650_2 $$2MeSH$$aBrain Mapping
000258000 650_2 $$2MeSH$$aMemory, Episodic
000258000 650_2 $$2MeSH$$aMagnetic Resonance Imaging: methods
000258000 650_2 $$2MeSH$$aNeuropsychological Tests
000258000 7001_ $$0P:(DE-2719)9000770$$aSoch, Joram$$b1$$udzne
000258000 7001_ $$0P:(DE-2719)9000615$$aKizilirmak, Jasmin$$b2$$udzne
000258000 7001_ $$0P:(DE-2719)9002356$$aFischer, Larissa$$b3$$udzne
000258000 7001_ $$0P:(DE-2719)9001467$$aSchütze, Hartmut$$b4$$udzne
000258000 7001_ $$0P:(DE-2719)2812914$$aAssmann, Anne$$b5$$udzne
000258000 7001_ $$aBehnisch, Gusalija$$b6
000258000 7001_ $$aFeldhoff, Hannah$$b7
000258000 7001_ $$aKnopf, Lea$$b8
000258000 7001_ $$aRaschick, Matthias$$b9
000258000 7001_ $$aSchult, Annika$$b10
000258000 7001_ $$00000-0002-7433-2716$$aSeidenbecher, Constanze I$$b11
000258000 7001_ $$0P:(DE-2719)2812398$$aYakupov, Renat$$b12$$udzne
000258000 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b13
000258000 7001_ $$0P:(DE-2719)2814326$$aSchott, Björn H$$b14$$eLast author
000258000 773__ $$0PERI:(DE-600)1492703-2$$a10.1002/hbm.26281$$gVol. 44, no. 8, p. 3283 - 3301$$n8$$p3283 - 3301$$tHuman brain mapping$$v44$$x1065-9471$$y2023
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