Journal Article

DZNE-2023-00530

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Single-value scores of memory-related brain activity reflect dissociable neuropsychological and anatomical signatures of neurocognitive aging.

Richter, A. ; Soch, J.DZNE* ; Kizilirmak, J.DZNE* ; Fischer, L.DZNE* ; Schütze, H.DZNE* ; Assmann, A.Extern* ; Behnisch, G. ; Feldhoff, H. ; Knopf, L. ; Raschick, M. ; Schult, A. ; Seidenbecher, C. I. ; Yakupov, R.DZNE* ; Düzel, E.DZNE* ; Schott, B. H. (Last author)DZNE*

2023
Wiley-Liss New York, NY

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Please use a persistent id in citations: doi:10.1002/hbm.26281

Abstract: Memory-related functional magnetic resonance imaging (fMRI) activations show age-related differences across multiple brain regions that can be captured in summary statistics like single-value scores. Recently, we described two single-value scores reflecting deviations from prototypical whole-brain fMRI activity of young adults during novelty processing and successful encoding. Here, we investigate the brain-behavior associations of these scores with age-related neurocognitive changes in 153 healthy middle-aged and older adults. All scores were associated with episodic recall performance. The memory network scores, but not the novelty network scores, additionally correlated with medial temporal gray matter and other neuropsychological measures including flexibility. Our results thus suggest that novelty-network-based fMRI scores show high brain-behavior associations with episodic memory and that encoding-network-based fMRI scores additionally capture individual differences in other aging-related functions. More generally, our results suggest that single-value scores of memory-related fMRI provide a comprehensive measure of individual differences in network dysfunction that may contribute to age-related cognitive decline.

Keyword(s): Middle Aged (MeSH) ; Young Adult (MeSH) ; Humans (MeSH) ; Aged (MeSH) ; Aging: psychology (MeSH) ; Brain: diagnostic imaging (MeSH) ; Mental Recall (MeSH) ; Brain Mapping (MeSH) ; Memory, Episodic (MeSH) ; Magnetic Resonance Imaging: methods (MeSH) ; Neuropsychological Tests (MeSH) ; cognitive aging ; episodic memory ; fMRI ; hippocampus ; memory impairment ; subsequent memory effect

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Contributing Institute(s):

1. Epigenetics and Systems Medicine in Neurodegenerative Diseases (AG Fischer)
2. Clinical Dementia Research (Göttingen) (Clinical Dementia Research (Göttingen))
3. Molecular biomarkers for predictive diagnostics of neurodegenerative diseases (AG Wiltfang)
4. Multimodal Neuroimaging (AG Maaß)
5. Clinical Neurophysiology and Memory (AG Düzel)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)
2. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2023

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Database coverage:
; ; ; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DOAJ Seal ; Ebsco Academic Search ; IF < 5 ; JCR ; Nationallizenz ; PubMed Central ; SCOPUS ; Web of Science Core Collection

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