TY  - JOUR
AU  - Richter, Anni
AU  - Soch, Joram
AU  - Kizilirmak, Jasmin
AU  - Fischer, Larissa
AU  - Schütze, Hartmut
AU  - Assmann, Anne
AU  - Behnisch, Gusalija
AU  - Feldhoff, Hannah
AU  - Knopf, Lea
AU  - Raschick, Matthias
AU  - Schult, Annika
AU  - Seidenbecher, Constanze I
AU  - Yakupov, Renat
AU  - Düzel, Emrah
AU  - Schott, Björn H
TI  - Single-value scores of memory-related brain activity reflect dissociable neuropsychological and anatomical signatures of neurocognitive aging.
JO  - Human brain mapping
VL  - 44
IS  - 8
SN  - 1065-9471
CY  - New York, NY
PB  - Wiley-Liss
M1  - DZNE-2023-00530
SP  - 3283 - 3301
PY  - 2023
AB  - Memory-related functional magnetic resonance imaging (fMRI) activations show age-related differences across multiple brain regions that can be captured in summary statistics like single-value scores. Recently, we described two single-value scores reflecting deviations from prototypical whole-brain fMRI activity of young adults during novelty processing and successful encoding. Here, we investigate the brain-behavior associations of these scores with age-related neurocognitive changes in 153 healthy middle-aged and older adults. All scores were associated with episodic recall performance. The memory network scores, but not the novelty network scores, additionally correlated with medial temporal gray matter and other neuropsychological measures including flexibility. Our results thus suggest that novelty-network-based fMRI scores show high brain-behavior associations with episodic memory and that encoding-network-based fMRI scores additionally capture individual differences in other aging-related functions. More generally, our results suggest that single-value scores of memory-related fMRI provide a comprehensive measure of individual differences in network dysfunction that may contribute to age-related cognitive decline.
KW  - Middle Aged
KW  - Young Adult
KW  - Humans
KW  - Aged
KW  - Aging: psychology
KW  - Brain: diagnostic imaging
KW  - Mental Recall
KW  - Brain Mapping
KW  - Memory, Episodic
KW  - Magnetic Resonance Imaging: methods
KW  - Neuropsychological Tests
KW  - cognitive aging (Other)
KW  - episodic memory (Other)
KW  - fMRI (Other)
KW  - hippocampus (Other)
KW  - memory impairment (Other)
KW  - subsequent memory effect (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36972323
C2  - pmc:PMC10171506
DO  - DOI:10.1002/hbm.26281
UR  - https://pub.dzne.de/record/258000
ER  -