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@ARTICLE{Richter:258000,
      author       = {Richter, Anni and Soch, Joram and Kizilirmak, Jasmin and
                      Fischer, Larissa and Schütze, Hartmut and Assmann, Anne and
                      Behnisch, Gusalija and Feldhoff, Hannah and Knopf, Lea and
                      Raschick, Matthias and Schult, Annika and Seidenbecher,
                      Constanze I and Yakupov, Renat and Düzel, Emrah and Schott,
                      Björn H},
      title        = {{S}ingle-value scores of memory-related brain activity
                      reflect dissociable neuropsychological and anatomical
                      signatures of neurocognitive aging.},
      journal      = {Human brain mapping},
      volume       = {44},
      number       = {8},
      issn         = {1065-9471},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {DZNE-2023-00530},
      pages        = {3283 - 3301},
      year         = {2023},
      abstract     = {Memory-related functional magnetic resonance imaging (fMRI)
                      activations show age-related differences across multiple
                      brain regions that can be captured in summary statistics
                      like single-value scores. Recently, we described two
                      single-value scores reflecting deviations from prototypical
                      whole-brain fMRI activity of young adults during novelty
                      processing and successful encoding. Here, we investigate the
                      brain-behavior associations of these scores with age-related
                      neurocognitive changes in 153 healthy middle-aged and older
                      adults. All scores were associated with episodic recall
                      performance. The memory network scores, but not the novelty
                      network scores, additionally correlated with medial temporal
                      gray matter and other neuropsychological measures including
                      flexibility. Our results thus suggest that
                      novelty-network-based fMRI scores show high brain-behavior
                      associations with episodic memory and that
                      encoding-network-based fMRI scores additionally capture
                      individual differences in other aging-related functions.
                      More generally, our results suggest that single-value scores
                      of memory-related fMRI provide a comprehensive measure of
                      individual differences in network dysfunction that may
                      contribute to age-related cognitive decline.},
      keywords     = {Middle Aged / Young Adult / Humans / Aged / Aging:
                      psychology / Brain: diagnostic imaging / Mental Recall /
                      Brain Mapping / Memory, Episodic / Magnetic Resonance
                      Imaging: methods / Neuropsychological Tests / cognitive
                      aging (Other) / episodic memory (Other) / fMRI (Other) /
                      hippocampus (Other) / memory impairment (Other) / subsequent
                      memory effect (Other)},
      cin          = {AG Fischer / Clinical Dementia Research (Göttingen) / AG
                      Wiltfang / AG Maaß / AG Düzel},
      ddc          = {610},
      cid          = {I:(DE-2719)1410002 / I:(DE-2719)1440015 /
                      I:(DE-2719)1410006 / I:(DE-2719)1311001 /
                      I:(DE-2719)5000006},
      pnm          = {352 - Disease Mechanisms (POF4-352) / 353 - Clinical and
                      Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-352 / G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36972323},
      pmc          = {pmc:PMC10171506},
      doi          = {10.1002/hbm.26281},
      url          = {https://pub.dzne.de/record/258000},
}