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000259698 037__ $$aDZNE-2023-00770
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000259698 1001_ $$aAndres-Alonso, Maria$$b0
000259698 245__ $$aGolgi satellites are essential for polysialylation of NCAM and expression of LTP at distal synapses.
000259698 260__ $$a[New York, NY]$$bElsevier$$c2023
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000259698 520__ $$aThe complex cytoarchitecture of neurons poses significant challenges for the maturation of synaptic membrane proteins. It is currently unclear whether locally secreted synaptic proteins bypass the Golgi or whether they traffic through Golgi satellites (GSs). Here, we create a transgenic GS reporter mouse line and show that GSs are widely distributed along dendrites and are capable of mature glycosylation, in particular sialylation. We find that polysialylation of locally secreted NCAM takes place at GSs. Accordingly, in mice lacking a component of trans-Golgi network-to-plasma membrane trafficking, we find fewer GSs and significantly reduced PSA-NCAM levels in distal dendrites of CA1 neurons that receive input from the temporoammonic pathway. Induction of long-term potentiation at those, but not more proximal, synapses is severely impaired. We conclude that GSs serve the need for local mature glycosylation of synaptic membrane proteins in distal dendrites and thereby contribute to rapid changes in synaptic strength.
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000259698 650_7 $$2Other$$aCP: Cell biology
000259698 650_7 $$2Other$$aCP: Neuroscience
000259698 650_7 $$2Other$$aGolgi satellites
000259698 650_7 $$2Other$$aNCAM
000259698 650_7 $$2Other$$apolysialylation
000259698 650_7 $$2Other$$asecretory trafficking
000259698 650_7 $$2Other$$asynaptic plasticity
000259698 650_7 $$2NLM Chemicals$$aNeural Cell Adhesion Molecules
000259698 650_2 $$2MeSH$$aMice
000259698 650_2 $$2MeSH$$aAnimals
000259698 650_2 $$2MeSH$$aLong-Term Potentiation: physiology
000259698 650_2 $$2MeSH$$aSynapses: metabolism
000259698 650_2 $$2MeSH$$aNeurons: metabolism
000259698 650_2 $$2MeSH$$aDendrites: metabolism
000259698 650_2 $$2MeSH$$aNeural Cell Adhesion Molecules: metabolism
000259698 7001_ $$aBorgmeyer, Maximilian$$b1
000259698 7001_ $$0P:(DE-2719)2814120$$aMirzapourdelavar, Hadi$$b2
000259698 7001_ $$aLormann, Jakob$$b3
000259698 7001_ $$aKlein, Kim$$b4
000259698 7001_ $$aSchweizer, Michaela$$b5
000259698 7001_ $$aHoffmeister-Ullerich, Sabine$$b6
000259698 7001_ $$0P:(DE-2719)2811208$$aOelschlegel, Anja Maria$$b7
000259698 7001_ $$0P:(DE-2719)2810577$$aDityatev, Alexander$$b8
000259698 7001_ $$0P:(DE-2719)2811905$$aKreutz, Michael R$$b9$$eLast author
000259698 773__ $$0PERI:(DE-600)2649101-1$$a10.1016/j.celrep.2023.112692$$gVol. 42, no. 7, p. 112692 -$$n7$$p112692$$tCell reports$$v42$$x2211-1247$$y2023
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