Journal Article

DZNE-2023-00770

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Golgi satellites are essential for polysialylation of NCAM and expression of LTP at distal synapses.

Andres-Alonso, M. ; Borgmeyer, M. ; Mirzapourdelavar, H.DZNE* ; Lormann, J. ; Klein, K. ; Schweizer, M. ; Hoffmeister-Ullerich, S. ; Oelschlegel, A. M.Extern* ; Dityatev, A.DZNE* ; Kreutz, M. R. (Last author)DZNE*

2023
Elsevier [New York, NY]

This record in other databases:    

Please use a persistent id in citations: doi:10.1016/j.celrep.2023.112692

Abstract: The complex cytoarchitecture of neurons poses significant challenges for the maturation of synaptic membrane proteins. It is currently unclear whether locally secreted synaptic proteins bypass the Golgi or whether they traffic through Golgi satellites (GSs). Here, we create a transgenic GS reporter mouse line and show that GSs are widely distributed along dendrites and are capable of mature glycosylation, in particular sialylation. We find that polysialylation of locally secreted NCAM takes place at GSs. Accordingly, in mice lacking a component of trans-Golgi network-to-plasma membrane trafficking, we find fewer GSs and significantly reduced PSA-NCAM levels in distal dendrites of CA1 neurons that receive input from the temporoammonic pathway. Induction of long-term potentiation at those, but not more proximal, synapses is severely impaired. We conclude that GSs serve the need for local mature glycosylation of synaptic membrane proteins in distal dendrites and thereby contribute to rapid changes in synaptic strength.

Keyword(s): Mice (MeSH) ; Animals (MeSH) ; Long-Term Potentiation: physiology (MeSH) ; Synapses: metabolism (MeSH) ; Neurons: metabolism (MeSH) ; Dendrites: metabolism (MeSH) ; Neural Cell Adhesion Molecules: metabolism (MeSH) ; CP: Cell biology ; CP: Neuroscience ; Golgi satellites ; NCAM ; polysialylation ; secretory trafficking ; synaptic plasticity ; Neural Cell Adhesion Molecules

---

Contributing Institute(s):

1. Clinical Neurophysiology and Memory (AG Düzel)
2. Molecular Neuroplasticity (AG Dityatev)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)
2. 351 - Brain Function (POF4-351) (POF4-351)

Appears in the scientific report 2023

---

Database coverage:
; ; ; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---