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000263610 0247_ $$2doi$$a10.1007/978-1-0716-3437-0_29
000263610 0247_ $$2pmid$$apmid:37639140
000263610 0247_ $$2ISSN$$a1064-3745
000263610 0247_ $$2ISSN$$a1940-6029
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000263610 037__ $$aDZNE-2023-00832
000263610 041__ $$aEnglish
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000263610 1001_ $$0P:(DE-2719)9002115$$aLovotti, Marta$$b0$$udzne
000263610 245__ $$aMonitoring of Inflammasome Activation of Macrophages and Microglia In Vitro, Part 2: Assessing Inflammasome Activation.
000263610 260__ $$aNew York, NY$$bSpringer US$$c2024
000263610 29510 $$aTissue-Resident Macrophages / Mass, Elvira (Editor) ; New York, NY : Springer US, 2024, Chapter 29 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-0716-3436-3=978-1-0716-3437-0 ; doi:10.1007/978-1-0716-3437-0
000263610 300__ $$a431 - 451
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000263610 3367_ $$0PUB:(DE-HGF)7$$2PUB:(DE-HGF)$$aContribution to a book$$bcontb$$mcontb$$s1694701678_30860
000263610 4900_ $$aMethods in Molecular Biology$$v2713
000263610 520__ $$aInflammasomes are macromolecular complexes that assemble upon the detection of cytoplasmic pathogen-associated or danger-associated signals and induce a necrotic type of cell death termed pyroptosis, facilitating pro-inflammatory cytokine release. Inflammasomes play a critical role in innate immunity and inflammatory response; however, they have also been associated with multiple diseases, including autoinflammatory and neurodegenerative conditions. In the following chapter, we describe methods to detect inflammasome activation and its downstream effects, including detection of ASC oligomerization, detection of activated caspase-1 and cleaved IL-1β, as well as read-outs for inflammasome-mediated cell death.
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000263610 650_7 $$2Other$$aASC speck
000263610 650_7 $$2Other$$aCytokine production
000263610 650_7 $$2Other$$aInflammasome
000263610 650_7 $$2Other$$aLDH release
000263610 650_7 $$2Other$$aPyroptosis
000263610 650_7 $$2Other$$aWestern blot
000263610 650_7 $$2NLM Chemicals$$aInflammasomes
000263610 650_7 $$0EC 3.4.22.36$$2NLM Chemicals$$aCaspase 1
000263610 650_2 $$2MeSH$$aMicroglia
000263610 650_2 $$2MeSH$$aInflammasomes
000263610 650_2 $$2MeSH$$aMacrophages
000263610 650_2 $$2MeSH$$aImmunity, Innate
000263610 650_2 $$2MeSH$$aCaspase 1
000263610 7001_ $$0P:(DE-2719)2810930$$aMangan, Matthew$$b1$$udzne
000263610 7001_ $$0P:(DE-2719)2811671$$aMcManus, Róisín M$$b2$$eFirst author$$udzne
000263610 7001_ $$0P:(DE-2719)9002209$$aShkarina, Kateryna$$b3$$eFirst author$$udzne
000263610 7001_ $$aVasconcelos, Matilde B$$b4
000263610 7001_ $$0P:(DE-2719)2000062$$aLatz, Eicke$$b5$$eLast author$$udzne
000263610 773__ $$a10.1007/978-1-0716-3437-0_29
000263610 8564_ $$uhttps://pub.dzne.de/record/263610/files/DZNE-2023-00832.pdf
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000263610 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811671$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
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000263610 9141_ $$y2024
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000263610 9201_ $$0I:(DE-2719)1013024$$kAG Latz$$lInnate Immunity in Neurodegeneration$$x0
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