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@INBOOK{Lovotti:263610,
      author       = {Lovotti, Marta and Mangan, Matthew and McManus, Róisín M
                      and Shkarina, Kateryna and Vasconcelos, Matilde B and Latz,
                      Eicke},
      title        = {{M}onitoring of {I}nflammasome {A}ctivation of
                      {M}acrophages and {M}icroglia {I}n {V}itro, {P}art 2:
                      {A}ssessing {I}nflammasome {A}ctivation.},
      volume       = {2713},
      address      = {New York, NY},
      publisher    = {Springer US},
      reportid     = {DZNE-2023-00832},
      isbn         = {978-1-0716-3436-3 (print)},
      series       = {Methods in Molecular Biology},
      pages        = {431 - 451},
      year         = {2024},
      comment      = {Tissue-Resident Macrophages / Mass, Elvira (Editor) ; New
                      York, NY : Springer US, 2024, Chapter 29 ; ISSN:
                      1064-3745=1940-6029 ; ISBN:
                      978-1-0716-3436-3=978-1-0716-3437-0 ;
                      doi:10.1007/978-1-0716-3437-0},
      booktitle     = {Tissue-Resident Macrophages / Mass,
                       Elvira (Editor) ; New York, NY :
                       Springer US, 2024, Chapter 29 ; ISSN:
                       1064-3745=1940-6029 ; ISBN:
                       978-1-0716-3436-3=978-1-0716-3437-0 ;
                       doi:10.1007/978-1-0716-3437-0},
      abstract     = {Inflammasomes are macromolecular complexes that assemble
                      upon the detection of cytoplasmic pathogen-associated or
                      danger-associated signals and induce a necrotic type of cell
                      death termed pyroptosis, facilitating pro-inflammatory
                      cytokine release. Inflammasomes play a critical role in
                      innate immunity and inflammatory response; however, they
                      have also been associated with multiple diseases, including
                      autoinflammatory and neurodegenerative conditions. In the
                      following chapter, we describe methods to detect
                      inflammasome activation and its downstream effects,
                      including detection of ASC oligomerization, detection of
                      activated caspase-1 and cleaved IL-1β, as well as read-outs
                      for inflammasome-mediated cell death.},
      keywords     = {Microglia / Inflammasomes / Macrophages / Immunity, Innate
                      / Caspase 1 / ASC speck (Other) / Cytokine production
                      (Other) / Inflammasome (Other) / LDH release (Other) /
                      Pyroptosis (Other) / Western blot (Other) / Inflammasomes
                      (NLM Chemicals) / Caspase 1 (NLM Chemicals)},
      cin          = {AG Latz},
      ddc          = {570},
      cid          = {I:(DE-2719)1013024},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)7},
      pubmed       = {pmid:37639140},
      doi          = {10.1007/978-1-0716-3437-0_29},
      url          = {https://pub.dzne.de/record/263610},
}