000263634 001__ 263634
000263634 005__ 20240724153059.0
000263634 0247_ $$2doi$$a10.5281/ZENODO.5904586
000263634 037__ $$aDZNE-2023-00852
000263634 1001_ $$0P:(DE-2719)2810271$$aTavosanis, Gaia$$b0
000263634 245__ $$aSoftware: APL synapses distribution on PN and KC meshes, primary data, calcium imaging macros and python scripts from Prisco et al. (v1)
000263634 260__ $$aZenodo$$c2022
000263634 3367_ $$2DCMI$$aSoftware
000263634 3367_ $$0PUB:(DE-HGF)33$$2PUB:(DE-HGF)$$aSoftware$$bsware$$msware$$s1721827802_7924
000263634 3367_ $$2BibTeX$$aMISC
000263634 3367_ $$06$$2EndNote$$aComputer Program
000263634 3367_ $$2ORCID$$aOTHER
000263634 3367_ $$2DataCite$$aSoftware
000263634 520__ $$aTo identify and memorize discrete but similar environmental inputs, the brain needs to distinguish between subtle differences of activity patterns in defined neuronal populations. The Kenyon cells of the Drosophila adult mushroom body (MB) respond sparsely to complex olfactory input, a property that is thought to support stimuli discrimination in the MB. To understand how this property emerges, we investigated the role of the inhibitory anterior paired lateral neuron (APL) in the input circuit of the MB, the calyx. Within the calyx, presynaptic boutons of projection neurons (PNs) form large synaptic microglomeruli (MGs) with dendrites of postsynaptic Kenyon cells (KCs). Combining EM data analysis and in vivo calcium imaging, we show that APL, via inhibitory and reciprocal synapses targeting both PN boutons and KC dendrites, normalizes odour-evoked representations in MGs of the calyx. APL response scales with the PN input strength and is regionalized around PN input distribution. Our data indicate that the formation of a sparse code by the Kenyon cells requires APL-driven normalization of their MG postsynaptic responses. This work provides experimental insights on how inhibition shapes sensory information representation in a higher brain centre, thereby supporting stimuli discrimination and allowing for efficient associative memory formation.
000263634 536__ $$0G:(DE-HGF)POF4-351$$a351 - Brain Function (POF4-351)$$cPOF4-351$$fPOF IV$$x0
000263634 588__ $$aDataset connected to DataCite
000263634 7001_ $$0P:(DE-2719)2812229$$aPrisco, Luigi$$b1$$udzne
000263634 773__ $$a10.5281/ZENODO.5904586
000263634 7870_ $$0DZNE-2022-00002$$aPrisco, Luigi et.al.$$dCambridge : eLife Sciences Publications, 2021$$iRelatedTo$$tThe anterior paired lateral neuron normalizes odour-evoked activity in the Drosophila mushroom body calyx.
000263634 909CO $$ooai:pub.dzne.de:263634$$pVDB
000263634 9141_ $$y2022
000263634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810271$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000263634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812229$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000263634 9131_ $$0G:(DE-HGF)POF4-351$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vBrain Function$$x0
000263634 9201_ $$0I:(DE-2719)1013018$$kAG Tavosanis$$lDynamics of neuronal circuits$$x0
000263634 980__ $$asware
000263634 980__ $$aVDB
000263634 980__ $$aI:(DE-2719)1013018
000263634 980__ $$aUNRESTRICTED