Software

DZNE-2023-00852

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Software: APL synapses distribution on PN and KC meshes, primary data, calcium imaging macros and python scripts from Prisco et al. (v1)

Tavosanis, G.DZNE* ; Prisco, L.DZNE*

2022
Zenodo

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Please use a persistent id in citations: doi:10.5281/ZENODO.5904586

Abstract: To identify and memorize discrete but similar environmental inputs, the brain needs to distinguish between subtle differences of activity patterns in defined neuronal populations. The Kenyon cells of the Drosophila adult mushroom body (MB) respond sparsely to complex olfactory input, a property that is thought to support stimuli discrimination in the MB. To understand how this property emerges, we investigated the role of the inhibitory anterior paired lateral neuron (APL) in the input circuit of the MB, the calyx. Within the calyx, presynaptic boutons of projection neurons (PNs) form large synaptic microglomeruli (MGs) with dendrites of postsynaptic Kenyon cells (KCs). Combining EM data analysis and in vivo calcium imaging, we show that APL, via inhibitory and reciprocal synapses targeting both PN boutons and KC dendrites, normalizes odour-evoked representations in MGs of the calyx. APL response scales with the PN input strength and is regionalized around PN input distribution. Our data indicate that the formation of a sparse code by the Kenyon cells requires APL-driven normalization of their MG postsynaptic responses. This work provides experimental insights on how inhibition shapes sensory information representation in a higher brain centre, thereby supporting stimuli discrimination and allowing for efficient associative memory formation.

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Contributing Institute(s):

1. Dynamics of neuronal circuits (AG Tavosanis)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)

Appears in the scientific report 2022

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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article Prisco, L. (First author)DZNE* ; Deimel, S. H.Extern* ; Yeliseyeva, H.DZNE* ; Fiala, A.Extern* ; Tavosanis, G. (Last author)DZNE*
The anterior paired lateral neuron normalizes odour-evoked activity in the Drosophila mushroom body calyx.
eLife 10, e74172 (2021) [10.7554/eLife.74172]2021   Files  Fulltext Fulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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