TY  - JOUR
AU  - Tzilivaki, Alexandra
AU  - Tukker, Jan Johan
AU  - Maier, Nikolaus
AU  - Poirazi, Panayiota
AU  - Sammons, Rosanna P
AU  - Schmitz, Dietmar
TI  - Hippocampal GABAergic interneurons and memory.
JO  - Neuron
VL  - 111
IS  - 20
SN  - 0896-6273
CY  - New York, NY
PB  - Elsevier
M1  - DZNE-2023-01026
SP  - 3154 - 3175
PY  - 2023
AB  - One of the most captivating questions in neuroscience revolves around the brain's ability to efficiently and durably capture and store information. It must process continuous input from sensory organs while also encoding memories that can persist throughout a lifetime. What are the cellular-, subcellular-, and network-level mechanisms that underlie this remarkable capacity for long-term information storage? Furthermore, what contributions do distinct types of GABAergic interneurons make to this process? As the hippocampus plays a pivotal role in memory, our review focuses on three aspects: (1) delineation of hippocampal interneuron types and their connectivity, (2) interneuron plasticity, and (3) activity patterns of interneurons during memory-related rhythms, including the role of long-range interneurons and disinhibition. We explore how these three elements, together showcasing the remarkable diversity of inhibitory circuits, shape the processing of memories in the hippocampus.
KW  - Interneurons: physiology
KW  - Hippocampus: physiology
KW  - connectivity (Other)
KW  - disinhibition (Other)
KW  - hippocampus (Other)
KW  - interneurons (Other)
KW  - long-range projections (Other)
KW  - memory (Other)
KW  - oscillations (Other)
KW  - plasticity (Other)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC10593603
C6  - pmid:37467748
DO  - DOI:10.1016/j.neuron.2023.06.016
UR  - https://pub.dzne.de/record/265751
ER  -