Journal Article (Review Article)

DZNE-2023-01026

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Hippocampal GABAergic interneurons and memory.

Tzilivaki, A. ; Tukker, J. J.DZNE* ; Maier, N. ; Poirazi, P. ; Sammons, R. P. ; Schmitz, D. (Last author)DZNE*

2023
Elsevier New York, NY

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Please use a persistent id in citations: doi:10.1016/j.neuron.2023.06.016

Abstract: One of the most captivating questions in neuroscience revolves around the brain's ability to efficiently and durably capture and store information. It must process continuous input from sensory organs while also encoding memories that can persist throughout a lifetime. What are the cellular-, subcellular-, and network-level mechanisms that underlie this remarkable capacity for long-term information storage? Furthermore, what contributions do distinct types of GABAergic interneurons make to this process? As the hippocampus plays a pivotal role in memory, our review focuses on three aspects: (1) delineation of hippocampal interneuron types and their connectivity, (2) interneuron plasticity, and (3) activity patterns of interneurons during memory-related rhythms, including the role of long-range interneurons and disinhibition. We explore how these three elements, together showcasing the remarkable diversity of inhibitory circuits, shape the processing of memories in the hippocampus.

Keyword(s): Interneurons: physiology (MeSH) ; Hippocampus: physiology (MeSH) ; connectivity ; disinhibition ; hippocampus ; interneurons ; long-range projections ; memory ; oscillations ; plasticity

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Contributing Institute(s):

1. Network Dysfunction (AG Schmitz)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)

Appears in the scientific report 2023

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 15 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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