Journal Article

DZNE-2023-01129

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Brain-wide continuous functional ultrasound imaging for real-time monitoring of hemodynamics during ischemic stroke.

Brunner, C. ; Denis, N. L.DZNE* ; Gertz, K.DZNE* ; Grillet, M. ; Montaldo, G. ; Endres, M.DZNE* ; Urban, A.

2024
Sage London

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Please use a persistent id in citations: doi:10.1177/0271678X231191600

Abstract: Ischemic stroke occurs abruptly causing sudden neurologic deficits, and therefore, very little is known about hemodynamic perturbations in the brain immediately after stroke onset. Here, functional ultrasound imaging was used to monitor variations in relative cerebral blood volume (rCBV) compared to baseline. rCBV levels were analyzed brain-wide and continuously at high spatiotemporal resolution (100 μm, 2 Hz) until 70mins after stroke onset in rats. We compared two stroke models, with either a permanent occlusion of the middle cerebral artery (MCAo) or a tandem occlusion of both the common carotid and middle cerebral arteries (CCAo + MCAo). We observed a typical hemodynamic pattern, including a quick drop of the rCBV after MCAo, followed by spontaneous reperfusion of several brain regions located in the vicinity of the ischemic core. The severity and location of the ischemia were variable within groups. On average, the severity of the ischemia was in good agreement with the lesion volume (24 hrs after stroke) for MCAo group, while larger for the CCAo + MCAo model. For both groups, we observed that infarcts extended to initially non-ischemic regions located rostrally to the ischemic core. These regions strongly colocalize with the origin of transient hemodynamic events associated with spreading depolarizations.

Keyword(s): Rats (MeSH) ; Animals (MeSH) ; Brain Ischemia: pathology (MeSH) ; Ischemic Stroke: pathology (MeSH) ; Brain: pathology (MeSH) ; Stroke: pathology (MeSH) ; Ischemia: pathology (MeSH) ; Ultrasonography (MeSH) ; Hemodynamics (MeSH) ; Disease Models, Animal (MeSH) ; Infarction, Middle Cerebral Artery: pathology (MeSH) ; Brain-wide imaging ; functional ultrasound imaging ; ischemic lesion prediction ; ischemic stroke ; spreading depolarization

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Contributing Institute(s):

1. Interdisciplinary Dementia Research (AG Endres)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2024

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; National-Konsortium ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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