%0 Journal Article
%A Kapadia, Akshay
%A Theil, Sandra
%A Opitz, Sabine
%A Villacampa, Nàdia
%A Beckert, Hannes
%A Schoch, Susanne
%A Heneka, Michael T
%A Kumar, Sathish
%A Walter, Jochen
%T Phosphorylation-state dependent intraneuronal sorting of Aβ differentially impairs autophagy and the endo-lysosomal system.
%J Autophagy
%V 20
%N 1
%@ 1554-8627
%C Abingdon, Oxon
%I Taylor & Francis
%M DZNE-2024-00004
%P 166 - 187
%D 2024
%X AD: Alzheimer disease; APP: amyloid beta precursor protein; ATG: autophagy related; Aβ: amyloid-β; CTSD: cathepsin D; DAPI: 4',6-diamidino-2-phenylindole; EEA1: early endosome antigen 1; FA: formic acid; GFP: green fluorescent protein; LAMP2: lysosomal-associated membrane protein 2; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MAP2: microtubule-associated protein 2; nmAβ: non-modified amyloid-β; npAβ: non-phosphorylated amyloid-β; pAβ: phosphorylated amyloid-β; p-Ser26Aβ: amyloid-β phosphorylated at serine residue 26; p-Ser8Aβ: amyloid-β phosphorylated at serine residue 8; RAB: RAB, member RAS oncogene family; RFP: red fluorescent protein; SQSTM1/p62: sequestome 1; YFP: yellow fluorescent protein.
%K Autophagy: physiology
%K Amyloid beta-Peptides: metabolism
%K Phosphorylation
%K Green Fluorescent Proteins: metabolism
%K Lysosomes: metabolism
%K Serine
%K Alzheimer’s disease (Other)
%K Alzheimer’s disease (Other)
%K Alzheimer’s disease (Other)
%K Alzheimer’s disease (Other)
%K autophagic flux (Other)
%K neurodegeneration (Other)
%K phosphorylated Aβ (Other)
%K post-translationally modified Aβ (Other)
%K vesicular trafficking (Other)
%K Amyloid beta-Peptides (NLM Chemicals)
%K Green Fluorescent Proteins (NLM Chemicals)
%K Serine (NLM Chemicals)
%K phosphorylated Aβ (Other)
%K post-translationally modified Aβ (Other)
%K phosphorylated Aβ (Other)
%K post-translationally modified Aβ (Other)
%K phosphorylated Aβ (Other)
%K post-translationally modified Aβ (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37642583
%2 pmc:PMC10761119
%R 10.1080/15548627.2023.2252300
%U https://pub.dzne.de/record/266741