Journal Article

DZNE-2024-00004

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Phosphorylation-state dependent intraneuronal sorting of Aβ differentially impairs autophagy and the endo-lysosomal system.

Kapadia, A. ; Theil, S. ; Opitz, S.DZNE* ; Villacampa, N.DZNE* ; Beckert, H. ; Schoch, S. ; Heneka, M. T.DZNE* ; Kumar, S. ; Walter, J.Extern*

2024
Taylor & Francis Abingdon, Oxon

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Please use a persistent id in citations: doi:10.1080/15548627.2023.2252300

Abstract: AD: Alzheimer disease; APP: amyloid beta precursor protein; ATG: autophagy related; Aβ: amyloid-β; CTSD: cathepsin D; DAPI: 4',6-diamidino-2-phenylindole; EEA1: early endosome antigen 1; FA: formic acid; GFP: green fluorescent protein; LAMP2: lysosomal-associated membrane protein 2; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MAP2: microtubule-associated protein 2; nmAβ: non-modified amyloid-β; npAβ: non-phosphorylated amyloid-β; pAβ: phosphorylated amyloid-β; p-Ser26Aβ: amyloid-β phosphorylated at serine residue 26; p-Ser8Aβ: amyloid-β phosphorylated at serine residue 8; RAB: RAB, member RAS oncogene family; RFP: red fluorescent protein; SQSTM1/p62: sequestome 1; YFP: yellow fluorescent protein.

Keyword(s): Autophagy: physiology (MeSH) ; Amyloid beta-Peptides: metabolism (MeSH) ; Phosphorylation (MeSH) ; Green Fluorescent Proteins: metabolism (MeSH) ; Lysosomes: metabolism (MeSH) ; Serine (MeSH) ; Alzheimer’s disease ; Alzheimer’s disease ; Alzheimer’s disease ; Alzheimer’s disease ; autophagic flux ; neurodegeneration ; phosphorylated Aβ ; post-translationally modified Aβ ; vesicular trafficking ; Amyloid beta-Peptides ; Green Fluorescent Proteins ; Serine ; phosphorylated Aβ ; post-translationally modified Aβ ; phosphorylated Aβ ; post-translationally modified Aβ ; phosphorylated Aβ ; post-translationally modified Aβ

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Contributing Institute(s):

1. Neuroinflammation, Biomarker (AG Heneka ; AG Heneka)
2. Technology Transfer and Industry Collaborations Unit (Tech Transfer)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2024

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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