TY  - JOUR
AU  - Kapadia, Akshay
AU  - Theil, Sandra
AU  - Opitz, Sabine
AU  - Villacampa, Nàdia
AU  - Beckert, Hannes
AU  - Schoch, Susanne
AU  - Heneka, Michael T
AU  - Kumar, Sathish
AU  - Walter, Jochen
TI  - Phosphorylation-state dependent intraneuronal sorting of Aβ differentially impairs autophagy and the endo-lysosomal system.
JO  - Autophagy
VL  - 20
IS  - 1
SN  - 1554-8627
CY  - Abingdon, Oxon
PB  - Taylor & Francis
M1  - DZNE-2024-00004
SP  - 166 - 187
PY  - 2024
AB  - AD: Alzheimer disease; APP: amyloid beta precursor protein; ATG: autophagy related; Aβ: amyloid-β; CTSD: cathepsin D; DAPI: 4',6-diamidino-2-phenylindole; EEA1: early endosome antigen 1; FA: formic acid; GFP: green fluorescent protein; LAMP2: lysosomal-associated membrane protein 2; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MAP2: microtubule-associated protein 2; nmAβ: non-modified amyloid-β; npAβ: non-phosphorylated amyloid-β; pAβ: phosphorylated amyloid-β; p-Ser26Aβ: amyloid-β phosphorylated at serine residue 26; p-Ser8Aβ: amyloid-β phosphorylated at serine residue 8; RAB: RAB, member RAS oncogene family; RFP: red fluorescent protein; SQSTM1/p62: sequestome 1; YFP: yellow fluorescent protein.
KW  - Autophagy: physiology
KW  - Amyloid beta-Peptides: metabolism
KW  - Phosphorylation
KW  - Green Fluorescent Proteins: metabolism
KW  - Lysosomes: metabolism
KW  - Serine
KW  - Alzheimer’s disease (Other)
KW  - Alzheimer’s disease (Other)
KW  - Alzheimer’s disease (Other)
KW  - Alzheimer’s disease (Other)
KW  - autophagic flux (Other)
KW  - neurodegeneration (Other)
KW  - phosphorylated Aβ (Other)
KW  - post-translationally modified Aβ (Other)
KW  - vesicular trafficking (Other)
KW  - Amyloid beta-Peptides (NLM Chemicals)
KW  - Green Fluorescent Proteins (NLM Chemicals)
KW  - Serine (NLM Chemicals)
KW  - phosphorylated Aβ (Other)
KW  - post-translationally modified Aβ (Other)
KW  - phosphorylated Aβ (Other)
KW  - post-translationally modified Aβ (Other)
KW  - phosphorylated Aβ (Other)
KW  - post-translationally modified Aβ (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37642583
C2  - pmc:PMC10761119
DO  - DOI:10.1080/15548627.2023.2252300
UR  - https://pub.dzne.de/record/266741
ER  -