Journal Article

DZNE-2024-00024

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies.

O'Keefe, J. H. ; Tintle, N. L. ; Harris, W. S. ; O'Keefe, E. L. ; Sala-Vila, A. ; Attia, J. ; Garg, G. M. ; Hure, A. ; Bork, C. S. ; Schmidt, E. B. ; Venø, S. K. ; Chien, K.-L. ; Chen, Y. A. ; Egert, S. ; Feldreich, T. R. ; Ärnlöv, J. ; Lind, L. ; Forouhi, N. G. ; Geleijnse, J. M. ; Pertiwi, K. ; Imamura, F. ; de Mello Laaksonen, V. ; Uusitupa, W. M. ; Tuomilehto, J. ; Laakso, M. ; Lankinen, M. A. ; Laurin, D. ; Carmichael, P.-H. ; Lindsay, J. ; Leander, K. ; Laguzzi, F. ; Swenson, B. R. ; Longstreth, W. T. ; Manson, J. E. ; Mora, S. ; Cook, N. R. ; Marklund, M. ; Melo van Lent, D. ; Murphy, R. ; Gudnason, V. ; Ninomiya, T. ; Hirakawa, Y. ; Qian, F. ; Sun, Q. ; Hu, F. ; Ardisson Korat, A. V. ; Risérus, U. ; Lázaro, I. ; Samieri, C. ; Le Goff, M. ; Helmer, C. ; Steur, M. ; Voortman, T. ; Ikram, M. K. ; Tanaka, T. ; Das, J. K. ; Ferrucci, L. ; Bandinelli, S. ; Tsai, M. ; Guan, W. ; Garg, P. ; Verschuren, W. M. M. ; Boer, J. M. A. ; Biokstra, A. ; Virtanen, J. ; Wagner, M.DZNE* ; Westra, J. ; Albuisson, L. ; Yamagishi, K. ; Siscovick, D. S. ; Lemaitre, R. N. ; Mozaffarian, D.

2024
Lippincott Williams & Wilkins Philadelphia, Pa.

This record in other databases:    

Please use a persistent id in citations: doi:10.1161/STROKEAHA.123.044281

Abstract: The effect of marine omega-3 PUFAs on risk of stroke remains unclear.We investigated the associations between circulating and tissue omega-3 PUFA levels and incident stroke (total, ischemic, and hemorrhagic) in 29 international prospective cohorts. Each site conducted a de novo individual-level analysis using a prespecified analytical protocol with defined exposures, covariates, analytical methods, and outcomes; the harmonized data from the studies were then centrally pooled. Multivariable-adjusted HRs and 95% CIs across omega-3 PUFA quintiles were computed for each stroke outcome.Among 183 291 study participants, there were 10 561 total strokes, 8220 ischemic strokes, and 1142 hemorrhagic strokes recorded over a median of 14.3 years follow-up. For eicosapentaenoic acid, comparing quintile 5 (Q5, highest) with quintile 1 (Q1, lowest), total stroke incidence was 17% lower (HR, 0.83 [CI, 0.76-0.91]; P<0.0001), and ischemic stroke was 18% lower (HR, 0.82 [CI, 0.74-0.91]; P<0.0001). For docosahexaenoic acid, comparing Q5 with Q1, there was a 12% lower incidence of total stroke (HR, 0.88 [CI, 0.81-0.96]; P=0.0001) and a 14% lower incidence of ischemic stroke (HR, 0.86 [CI, 0.78-0.95]; P=0.0001). Neither eicosapentaenoic acid nor docosahexaenoic acid was associated with a risk for hemorrhagic stroke. These associations were not modified by either baseline history of AF or prevalent CVD.Higher omega-3 PUFA levels are associated with lower risks of total and ischemic stroke but have no association with hemorrhagic stroke.

Keyword(s): Humans (MeSH) ; Prospective Studies (MeSH) ; Eicosapentaenoic Acid (MeSH) ; Docosahexaenoic Acids (MeSH) ; Hemorrhagic Stroke: epidemiology (MeSH) ; Fatty Acids, Omega-3 (MeSH) ; Stroke: epidemiology (MeSH) ; Ischemic Stroke (MeSH) ; Risk Factors (MeSH) ; atrial fibrillation ; cerebrovascular disease ; fish ; fish oil ; stroke ; Eicosapentaenoic Acid ; Docosahexaenoic Acids ; Fatty Acids, Omega-3

---

Contributing Institute(s):

1. Neuropsychology (AG Wagner)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2024

---

Database coverage:
; Allianz-Lizenz ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Essential Science Indicators ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---