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001     267497
005     20240808164649.0
024 7 _ |a 10.1016/j.neurobiolaging.2023.12.003
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024 7 _ |a pmid:38157587
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024 7 _ |a 0197-4580
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024 7 _ |a 1558-1497
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037 _ _ |a DZNE-2024-00143
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Levin, Fedor
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245 _ _ |a Longitudinal trajectories of cognitive reserve in hypometabolic subtypes of Alzheimer's disease.
260 _ _ |a Amsterdam [u.a.]
|c 2024
|b Elsevier Science
336 7 _ |a article
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520 _ _ |a Previous studies have demonstrated resilience to AD-related neuropathology in a form of cognitive reserve (CR). In this study we investigated a relationship between CR and hypometabolic subtypes of AD, specifically the typical and the limbic-predominant subtypes. We analyzed data from 59 Aβ-positive cognitively normal (CN), 221 prodromal Alzheimer's disease (AD) and 174 AD dementia participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) from ADNI and ADNIGO/2 phases. For replication, we analyzed data from 5 Aβ-positive CN, 89 prodromal AD and 43 AD dementia participants from ADNI3. CR was estimated as standardized residuals in a model predicting cognition from temporoparietal grey matter volumes and covariates. Higher CR estimates predicted slower cognitive decline. Typical and limbic-predominant hypometabolic subtypes demonstrated similar baseline CR, but the results suggested a faster decline of CR in the typical subtype. These findings support the relationship between subtypes and CR, specifically longitudinal trajectories of CR. Results also underline the importance of longitudinal analyses in research on CR.
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650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Alzheimer Disease: diagnostic imaging
|2 MeSH
650 _ 2 |a Alzheimer Disease: pathology
|2 MeSH
650 _ 2 |a Cognitive Reserve
|2 MeSH
650 _ 2 |a Brain: diagnostic imaging
|2 MeSH
650 _ 2 |a Brain: pathology
|2 MeSH
650 _ 2 |a Cognition
|2 MeSH
650 _ 2 |a Gray Matter: diagnostic imaging
|2 MeSH
650 _ 2 |a Gray Matter: pathology
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: pathology
|2 MeSH
650 _ 7 |a Alzheimer’s disease
|2 Other
650 _ 7 |a Alzheimer’s disease
|2 Other
650 _ 7 |a Alzheimer’s disease
|2 Other
650 _ 7 |a Alzheimer’s disease
|2 Other
650 _ 7 |a Cognitive reserve
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650 _ 7 |a FDG-PET
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650 _ 7 |a Mild cognitive impairment
|2 Other
650 _ 7 |a Prodromal AD
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650 _ 7 |a Subtypes
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700 1 _ |a Grothe, Michel J
|b 1
700 1 _ |a Dyrba, Martin
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700 1 _ |a Franzmeier, Nicolai
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700 1 _ |a Teipel, Stefan J
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700 1 _ |a Initiative, Alzheimer’s Disease Neuroimaging
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773 _ _ |a 10.1016/j.neurobiolaging.2023.12.003
|g Vol. 135, p. 26 - 38
|0 PERI:(DE-600)1498414-3
|p 26 - 38
|t Neurobiology of aging
|v 135
|y 2024
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856 4 _ |u https://pub.dzne.de/record/267497/files/DZNE-2024-00143%20SUP.docx
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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